探索植物来源外泌体中外泌体miRNA的生物标志物和皮肤改善作用.pdf

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1、Beautiful Science,Explore New TerritoriesExploring Biomarkers and Skin Improvement:Effects of Exosomal miRNAs in Plant-derived ExosomeGFC Life ScienceHuman&Microbiome Communicating LaboratoryDr.Mi Jung Kim(mj2.kimgfcos.co.kr)GFC Life Science,the Global Trendsetter and Leader in Bio-material R&DWhat

2、is Exosome?GFC Life Science,the Global Trendsetter and Leader in Bio-material R&DExosomes Have a nanoscale size,typically ranging from 50 to 200 nm They are composed of a phospholipid bilayer,similar to the cell membrane So,they gives them high biocompatibility and enables them to transfer genetic i

3、nformation from cell to cell Contains various active substances,including Proteins,DNAs,RNAs,Lipids,and more.Donor CellRecipient Cell(Molecular Cancer,2019)Multivesicular bodies(MVB)ExosomeSkin poreHair thicknessHow small an exosome?GFC Life Science,the Global Trendsetter and Leader in Bio-material

4、R&D Compare with skin pore and hair thickness Scale bar:100 nmSkin poreHairExosomeApproximately 400 times smaller than skin pore size and 600 times smaller than hair thickness3050 Exosome is Self-Navigating VesiclesGFC Life Science,the Global Trendsetter and Leader in Bio-material R&DExosomes are ap

5、proximately 100 times smaller than the nucleus(Key active ingredient in cosmetics Rock Samphire Callus derived Exosome(EVs):Cm-callus EVsmiRNA167is common miRNA in halophytes associated with abiotic stress tolerance,such as salinity and temperature.miR1*6miR1*6miR1*1miR3*9miR3*0miR3*3miR3*6miR3*7miR

6、4*3miR1*9_NmiR1*7_NmiR1*2_NmiR3*3_NmiR3*6_NmiR3*8_NmiR4*3_NmiR4*8_NmiR8*8_NNovelmiR167GFC Life Science,the Global Trendsetter and Leader in Bio-material R&DHalophyte derived exosome and miRNA167Cm-callus EVRock Samphire Stem-Exo Cma-miR167Cma-miR167MockCm-callus EVs 1%Cm-callus EVs 10%02040608010012