问题的核心.pdf

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1、20252025WELCOME2025KELLI RETALLICK-RILEYTHE HEART OF THE MATTERThe Heart of the MatterKelli Retallick-Riley,AGI President Concerns around heart deaths,BCHF have grown over the last several years Cattle succumbing to congestive heart failure have severe remodeling of the heartSource:Heaton,USDA-MARCS

2、TEP 3:STEP 3:Tackling Heart Health(Remodeling)through genetic selection.HeritabilityHeritability:Target Trait is heritable UtilityUtility:Actionable for Selection STEP 1:STEP 1:ScalabilityScalability:Measurable&accessibleSTEP 2:STEP 2:STEP 4:STEP 4:CompatibilityCompatibility:Trait relationships Path

3、ophysiology Bovine High Altitude Disease congestive heart failure at+5,000 feetStressor:Hypoxic environment:lower levels of pressurized oxygen Primary Cause:Altitude(Glover&Newsome,1917)Cure:None Screening Test:AvailableResult:High altitude disease(HAD)1.Hypertension 2.Right heart failure 3.Death Im

4、age courtesy of Dr.Jim Neary(2016)Understanding the genetics of PAP testing and its relationship to pulmonary hypertension and congestive heart failure StudyStudyHeritabilityHeritabilityBreedBreedEnns,et al.19920.46Angus(Seedstock,registered)Shirley,et al.,20080.34Angus(Seedstock,registered)Crawford

5、,20160.26Angus(Seedstock,research)Zeng,20130.56(weaning)0.31(yearling)Angus(Seedstock,research)Pauling,20160.25Angus(registered)American Angus AssociationAmerican Angus AssociationHeritabilityHeritabilityWeaning weightPostweaning GainMarblingCarcass weight0.270.280.480.40Put this in perspectivePut t

6、his in perspectiveSlides adapted from Speidel,2025 Correlations between moderate elevation and high elevation PAPPAP Scores heritable and(somewhat)scalable Provides opportunity to collect more dataPAP 5,500PAP 5,5000.37 0.100.79 0.23PAP 5,250PAP 5,2500.34 0.030.83 0.15PAP 5,000 ft Pulmonary artery b