GLP2 疗法的作用、可用性和未来.pdf

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1、IMPACT OF GLEPAGLUTIDE ON CLINICAL AND PATIENT REPORTED OUTCOMESIN PATIENTS WITH SHORT BOWEL SYNDROME CHRONIC INTESTINAL FAILURE:RESULTS OF PHASE 3 TRIALOley Foundation June 20231MedStar Georgetown University Hospital,Washington DC,USA,2Rigshospitalet,Copenhagen,Denmark;3University Hospital,Leuven,B

2、elgium,4Beaujon University Hospital,Paris,France;5Radboud University Medical Centre,Nijmegen,Netherlands;6Rostock University Medical Center,Rostock,Germany;7M.Pirogow Hospital,Lodz,Poland;8University College London Hospitals NHS Foundation Trust,London,UK;9Zealand Pharma,Copenhagen,Denmark;10Asklepi

3、os Medical School,Hamburg and Charit University Hospital,Berlin,Germany;11University of Nebraska Medical Center,Omaha,NE,USAOn behalf of the EASE InvestigatorsSukanya Subramanian1,Palle B Jeppesen1,Tim Vanuytsel2,Francisca Joly4,Geert Wanten5,Georg Lamprecht6,Marek Kunecki7,Farooq Rahman8,Thor SS Ni

4、elsen9,Lykke B Graff9,Mark Berner-Hansen9,Ulrich F Pape10,David F Mercer11 Takeda Zealand PharmaA/S2Sukanya Subramanian,DisclosuresGrants,research support,honoraria,or consultation fees from:Short Bowel Syndrome(SBS)3Pironi L et al.Clin Nutr 2015;34:17180.Intestinal failure is defined as the reducti

5、on of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes,such that intravenous supplementation is required to maintain health and/or growthThe reduction of gut absorptive function that doesnt require intravenous supplementation to maintain hea

6、lth and/or growth,can be considered as“intestinal insufficiency”Intravenous supplementation is required to maintain health and/or growth200cm small intestineMeier JJ et al.Gastroenterology 2006;130:4454;Brubaker PL.Comp Physiol 2018;8:1185210;Guan X.Am J Physiol Regul Integr Comp Physiol 2014;307:R5