智能数据驱动决策：生产环境中的微生物风险.pdf

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1、PIONEERINGDIAGNOSTICSMay 14,2025|Hannes PouseeleADAPTIVE SAMPLING:RISK-BASED ENVIRONMENTAL MONITORINGB I O M R I E U XOVERVIEW THE FACTORY:WITH A What is risk?How do we measure and model it?How do we improve observing the factory microbial state?How do we respond to issues?ADAPTIVE SAMPLING:andB I O

2、 M R I E U X3MICRO RISKS IN THE FACTORY ENVIRONMENTobserving the microbial state of the factory where is it hot?where is it cold?measuring the microbial state of specific locations at specific timesWhere do I look?How often do I look?How many samples can I afford?What action do I take?How does a lim

3、ited set of samples inform me about the factory state as a whole?B I O M R I E U X4WHAT CONSTITUTES RISK?Severity:if something happens,how bad is it?Positivity rate For a location that never tested positiveIf we measure location A once a month and location B once a week,Number of positivesNumber of

4、observationsEstimated riskUncertainty of the estimateB I O M R I E U X5MODEL vs.REALITYB I O M R I E U X6VALUE AT RISKESTIMATED RISKUNCERTAINTY OF THE ESTIMATEVALUE AT RISKHow bad does it get on a“usual”day?B I O M R I E U X By modifying sampling frequency,wewhile controlling for the sampling volume

5、.7REMAINING RISK AND SAMPLING OPTIMIZATIONRemaining risk at optimal frequency distribution(constrained)%improvementNumber of testsB I O M R I E U X8MIGRATIONDistanceDescription similarityProductTeleportationPeopleTimeRelative importance of different transmission mechanismsB I O M R I E U X9EXPLORATO

6、RY SAMPLINGTimeImprovement of time-to-detect through risk-informed samplingB I O M R I E U X10ADAPTIVE SAMPLINGRisk MigrationExpert-informed severityHIGH-RISK SAMPLING POINTSLOW-RISK SAMPLING POINTSWHAT MIGRATION MECHANISM HAS MOST IMPACT?P