猪圆环病毒3型相关疾病及母猪场动态流动规律 杨振 南京农业大学.pdf

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1、杨振，副教授Zhen Yang,DVM,MS,Associate Professor南京农业大学 动物医学院College of Veterinary Medicine,Nanjing Agricultural University中国中国长沙长沙2023中国李中国李曼养猪大会曼养猪大会Porcine circovirusuPorcine circovirus(PCV),Circovirus,Circoviridae family,circular,covalently closed,single-stranded DNA(ssDNA)genomeuPCV1:Non pathogenic uP

2、CV2:PMWS,PCVADuPCV3:UnclearuPCV4:Unknown clinical relevancePCV11974PCV21990sPCV32015PCV42020(Opriessnig,T.,and et.al,2020)PCV3 genomeuA circular,covalently closed single-stranded DNA genome(2,000 nt)uOpen reading frames(ORFs):ORF1:nonstructural replicase protein Rep(296-297 aa),48%similar to the rep

3、licase protein of PCV2 ORF2：capsid protein,the structural protein(214 aa),26-36%similar to the capsid protein of PCV2 ORF3：231 aa non-structural protein of unknown functionuGenotyping:PCV3a,3b;genotypes?(Palinski et al.,2016;Phan et al.,2016;Opriessnig et al.,2020)Key features of PCV3 epidemiologyuP

4、CV3 was first reported in U.S.swine herds in 2015uPCV3 has worldwide distribution uPCV3 was detected in 1993 in Sweden,1996 in Spain and China,and 2002 in the United Kingdom(Palinski et al.,2016;Phan et al.,2016;Klaumann et al.,2018;Ye et al.,2018;Sun et al.,2018;Collins et al,2017)Key features of P

5、CV3 epidemiology uTransmission and duration of PCV3 shedding PCV3 DNA has been detected in a variety of samples,including mummified and stillborn fetal tissues,serum,heart,lung,brain,lymph node,liver,kidney,et.al.Direct contact and vertical transmission PCV3 can be detected in blood for at least 42

6、days and in nasal secretions for 28 days post infection PCV3 can be detected for more than 5 months in wild boars uPotential to cause cross-species infections Detected in domestic pigs,wild boars,cattle,chamois,dog,donkey,fallow deer,laboratory mice,mouflon,roe deer and red deer(Czyewska et al.,2020