1306_Brodmann.pptx

1、Endovascular Laser-Assisted Lithotripsy,Marianne Brodmann,MD,PhDLandeskrankenhaus Universittsklinikum Graz Graz,Austria,2025 Boston Scientific Corporation or its affiliates.All rights reserved.,Disclosures,Consulting for Abbot,Boston Scientific,BD Bard,Teleflex,Cook Medical,Cordis,Medtronic,Reflow,S

2、hockwave,Angiodynamics,Penumbra,SEISMIQTM Intravascular Lithotripsy System Design Goals,3,SEISMIQ is a Next-Generation IVL Platform Designed to Provide an Enhanced User Experience,Deliver MoreEnergy Per Pulse,Highly Deliverable Catheters,ConsistentAcoustic Energy,On/Off Emitter Selectivity,Improved

3、EmitterVisibility,Real-TimeFeedback,Design Goal:Increase available pulses versus existing options,Design Goal:Deliverability in a variety of complex clinical situations,Design Goal:Deliver consistent acoustic energy across emitters,Design Goal:Improved emitter visibility versus existing options,Desi

4、gn Goal:Select which emitters deliver therapy&preserve pulses,Design Goal:Provide user with feedback on impact of therapy,2025 Boston Scientific Corporation or its affiliates.All rights reserved.,510(k)cleared for peripheral use.Caution:Investigational Device for coronary use.Limited by Federal(or U

5、S)law to investigational use only.Products shown for informational purposes only not meant as a promotion or offer for sale certain components are pending CE Mark,not available for sale in the European Economic Area(EEA).,Adapted from Phys.Chem.Chem.Phys.,2013,15,3027-46,Mechanism of Action(MoA),Aco

6、ustic Profile,Laser energy converted to acoustic pressure waves within the balloon laser hits metallic backstop creating a plasma eventInitial pressure waves fracture calciumSecondary cavitation bubble expands the fracture,Peripheral Emitter Station,P=Pressure(ATM),P,P,P,P,SEISMIQTM Intravascular Li