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1、7/24/201911Advanced-FlowTMReactor Technologies 2019 Corning Incorporated?-?021-22152888 ext.1480,15240518103,CORNING ADVANCED-FLOW REACTORTHE FUTURE FLOWS THROUGH2Advanced-FlowTMReactor Technologies 2019 Corning Incorporated I.?II.?III.?IV.?V.?VI.?7/24/201923Advanced-FlowTMReactor Technologies 2019

2、Corning Incorporated I?I?45%?27%?2019?22.95%?10.72%?21.09%?2019?40.43%?(?)?2018?FDA?38?18?(?)Original:?WeChatID F_chemical2018-11-13?WeChatID About Feature 2018-10-22?WeChatID chempub 2-17-10-23?WeChatID IOLFHG 2019-07-174Advanced-FlowTMReactor Technologies 2019 Corning Incorporated I?I?0201030506?0

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4、947Advanced-FlowTMReactor Technologies 2019 Corning Incorporated II?AFR?+?8Advanced-FlowTMReactor Technologies 2019 Corning Incorporated II?7/24/201959Advanced-FlowTMReactor Technologies 2019 Corning Incorporated?1?2?3?18-20bar200C110C25C-10CII?220C40%?30%NaOH?AFRSiC,?/?0.00680.0024?,?/?2?50%HF?0.01

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6、rning Incorporated III?-4?Org.Process Res.Dev.2017,21,273?276?44%?3?95%?AFR?95%?FAFR?1)?2)?3)?4)API?5)?7/24/2019815Advanced-FlowTMReactor Technologies 2019 Corning Incorporated III?-5?CHF3?CHF2Cl?H2NOHCHF2H2NOEflornithine?CHF3:76%yieldCHF2Cl:37%-40%C.Oliver Kappe et al,Green Chem,2018,20,108-11216Ad