1、AACR CANCER PROGRESS REPORT 2025AACR.org CancerProgressReport.org#CancerProgressReportFORUNIFYINGA CONTINUUM OFINNOVATIONIMPACTANDCANCERSCIENCEMEDICINE:Spotlight on ADVANCES IN BLOOD CANCERAACR CANCER PROGRESS REPORT 2025ISBN:979-8-9857852-8-9AACR CANCER PROGRESS REPORT 2025AACR.org CancerProgressRe

2、port.org#CancerProgressReportPLEASE CITE THIS REPORT AS:American Association for Cancer Research.AACR Cancer Progress Report 2025.Accessed:Month Day,Year.Available from:LinkTable of ContentsMessage From AACR .1Executive Summary .3Snapshot of a Year of Progress .12Cancer in 2025 .14Research:Driving P

3、rogress Against Cancer .14Cancer:An Ongoing Challenge .18Inequities in the Burden of Cancer in the United States.19Variable Progress Against Different Types of Cancer and Stages of Diagnosis.21The Growing Population Burden of Cancer.23The Global Burden of Cancer.24Funding Cancer Research:A Vital Inv

4、estment .26Understanding the Path to Cancer Development .29Cancer Development:Generating Knowledge Through Basic Research .29Basic Research Decoding Cancers Complexities.31Cancer Development:Translating Knowledge to Understand the Biology of Cancer .34Influences Inside the Cell.34Genetic Alterations

5、 .34RNA Variations .37Protein Modifications .38Epigenetic Changes .40Influences Outside the Cell.40Circulatory and Immune Systems .41The Nervous System .43Microbiome .44Tumor Microenvironment .45Cancer Development:Integrating Knowledge to Advance Precision Medicine .46Technological Innovations Fueli

6、ng Precision Medicine.46Reducing the Risk of Cancer Development .51Eliminate Tobacco Use .53Maintain a Healthy Weight,Eat a Healthy Diet,and Stay Active .56Reduce Alcohol Consumption .61Protect Skin From UV Exposure .62Prevent and Eliminate Infection From Cancer-causing Pathogens .64Limit Exposure t