1、 As filed with the Securities and Exchange Commission on October 18,2024 Registration No.333-282231 UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington,D.C.20549 Amendment No.1to FORM S-1 REGISTRATION STATEMENTUNDERTHE SECURITIES ACT OF 1933 SHUTTLE PHARMACEUTICALS HOLDINGS,INC.(Exact name of
2、registrant as specified in its charter)Delaware 2834 82-5089826(State or other jurisdictionof incorporation or organization)(Primary Standard IndustrialClassification Code Number)(I.R.S.EmployerIdentification Number)401 Professional Drive,Suite 260Gaithersburg,MD 20879(240)430-4212(Address,including
3、 zip code,and telephone number,includingarea code,of registrants principal executive office)Anatoly Dritschilo,M.D.Chief Executive OfficerShuttle Pharmaceuticals Holdings,Inc.401 Professional Drive,Suite 260Gaithersburg,MD 20879(240)430-4212(Name,address,including zip code,and telephone number,inclu
4、ding area code,of agent for service)Copies to:Megan J.Penick,Esq.Ron Ben-Bassat,Esq.Eric Victorson,Esq.Dorsey&Whitney LLPSullivan&Worcester LLP51 W.52nd St1251 Avenue of the AmericasNew York,NY 10019New York,NY 10020(212)415-9200(212)660-3000 Approximate date of commencement of proposed sale to the
5、public:As soon as practicable after this registration statement is declared effective.If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of1933 check the following box:If this Form is filed to regist
6、er additional securities for an offering pursuant to Rule 462(b)under the Securities Act,please check the following box andlist the Securities Act registration statement number of the earlier effective registration statement for the same offering.If this Form is a post-effective amendment filed purs