1、?https:/?https:/?https:/?02?&?&?03?04?01?05?https:/行业概论?https:/?研?Evolution?of?drug?delivery?systems:?From?1950?to?2020?and?beyond?Dissolution?的?Diffusion?Osmosis?Ionexchange?封?1950-1990?封?封?siRNA?mRNA?1990-2030? ? ? ? ? ? ?https:/1995FDA ? ? ? ? ? ? ? ? ?Doxil2008? ? ? ? ? ?ThermoDox ? ?III?2011?EX
2、PAREL副?2014?II?2017?/?副?2018?副?2018?LNP?RNAi?副?2021?溶?I?20?https:/?5?7.49%?2017?13.80?51.52?26.78%?1?Pacira ?Exparel?封?8.179.5911.5913.8118.0466.486271.758875.102482.046888.73402550752013201420152016201720132017?务?2?1.21.31.84.755.1Ambisome?B?Onivyde?ONPATTRO?RNAi?Exparel?2021?3?研?1?2?3?研?5?https:/5
3、3%49%48%44%34%17%2%2%2%2%2%2%17%12%9%7%8%10%14%18%21%30%38%50%13%19%21%17%18%22%0%10%20%30%40%50%60%70%80%90%100%2016201720182019202020212016-2021?1? ?B? ? ?溶?32.71343.852.40862.261.54657.50102030405060702016201720182019202020212016-2021?1 ?2019?油?盛?6262?62?研?1?https:/技术与壁垒分析?https:/?务?封?务?(Liposome
4、s)?(?)?:?:?:?:?https:/?研?1. ?100nm?2. ?1001000nm?/?PH?/?研?https:/? ? ? ? ?封?封?Lipoid GmbH?AVANTI?Genzyme?NOF?NFC?540?1500?3000?1?LNP?100nm?90%?副? ? ? ? ?研?1?研?https:/?9?(LNP)(LNP)?LNP?(?)?(?)?(?LNP?封?)?Alnylam?Onpattro?2018?, ?SynerGene Therapeutics?SGT-53?II?DepoFoamDepoFoam?Pacira?Exparel?2011?The
5、rmoDoxThermoDox?封?Celsion? ThermoDox ?III?Regulon?Lipoplatin?III?pHpH?pH?pH?封? pH?https:/?LNP?LNP?(?)?(?)?pKa?LNP?/?LNPVS?LNP?组分所占比例阳离子磷脂(可电离)约50%辅助磷脂(中性)约10%胆固醇约38.5%PEG化磷脂约1.5%LNP?LNP?mRNA?ionizable lipids?PEGylated lipid?研?Lipidsand Lipid?Derivatives?for?RNA?Delivery?LNP?Lipid?nanoparticle?https:
6、/LNP?MacLachlan?Madden?Inex?Inex?Protiva? MacLachlan ? ?Alnylam?LNP?Inex?MacLachlan?Tekmira?Madden?Madden?Acuitas ?Moderna?Arbutus?Tekmira ?Acuitas? Arbutus?Acuitas?MacLachlan?Tekmira?Alnylam?Alnylam?Tekmira 6,500?Tekmira? Acuitas?Madden?Cullis?Acuitas Therapeutics?Alnylam?Genevant Sciences? Tekmira