朱汉守-PRRSV感染的疫苗接种和免疫.pdf

1、PRRS virus vaccination&control in pigs 猪蓝耳病毒免疫和控制HanSoo Joo,DVM,PhD 朱汉守，DVM，博士Professor Emeritus 荣誉退休教授University of Minnesota 明尼苏达大学4/26/2024一带一路国际生猪产业大会History of PRRS 蓝耳病历史z 1987 1991:Mystery swine disease(unknown),SIRS,PEARS,Blue ear,PRRS 猪神秘病（未知），猪繁殖障碍综合征，猪流行性流产和呼吸综合征，蓝耳，猪繁殖与呼吸综合征z 1991:Etiolog

2、ic agent(Lelystad virus,VR-2332)was identified using primary PAM cells 病原体（莱利斯塔德病毒，VR-2332）的鉴定使用了原代猪肺泡巨噬细胞z 1993:MARC-145 cell was cloned from MA-104 line cells 从MA-104细胞系克隆出MARC-145细胞z 1994:First MLV vaccine(VR-2332)第一个弱毒疫苗（VR-2332）z Homologous inactivated vaccine 同源性灭活疫苗yBEI inactivated vaccine 二乙

3、烯亚胺灭活苗yMJ vaccine(Envelope proteins enriched vaccine)MJ疫苗（囊膜蛋白富集疫苗）Efficacy of PRRS MLV or inactivated vaccine:蓝耳弱毒苗或灭活苗的功效：May be effective or ineffective 可能有效或无效一带一路国际生猪产业大会PRRSV causes two different diseases蓝耳病毒导致两种不同疾病Late-term abortion,Premature farrowing,stillborn&mummified fetuses In pregnant

4、 sows 怀怀孕孕母母猪猪妊妊娠娠晚晚期期流流产产，早早产产，死死胎胎和和木木乃乃伊伊Respiratory diseases with interstitial pneumonia in growing pigs 生长长猪间间质质性肺炎呼吸道疾病一带一路国际生猪产业大会Pathogenesis of PRRSV infection in pregnant sows 妊娠母猪感染蓝耳的病理机制 z Transplacental infection is caused by viremia and may occur in any stage of pregnancy z 任何妊娠阶段都可能发

5、生病毒血症导致的经胎盘感染z Fetal infection and tissue damage occur around 70 days of gestation when susceptible alveolar macrophages are formed in the fetus 胎儿感染和组织损失发生在妊娠期70天左右，这时胎儿体内形成易感肺泡巨噬细胞z Abortion and pre-mature farrowing are caused by high fever,and no evidence was found placental lesion.流产和早产是由发烧引起，没有

6、证据证明胎盘损伤。z Stillbirth and mummification are caused by viral infection z 死胎和木乃伊胎是由病毒感染引起Viremia can be prevented by humoral immunity alone 单独的体液免疫就可以阻止病毒血症Following on-farm outbreak,normal litter can be expected when mummies length show 17cm(70 days of gestation).农场暴发后，当木乃伊胎长度17厘米时预期窝产仔正常（妊娠70天）No mu