精准患者：我的罕见癌症和临床试验经验.pptx

1、,My Experience With Rare Cancer and Clinical Trials,Presented by:,November 6,2024,allenchankowsky,Allen Chankowsky,Objectives,My cancer experience and why I owe my life to precision medicine,The importance of my advocacy work and the inclusion of the patient voice,A shining example of an innovative

2、decentralized clinical trial in the United States,An example of a Canadian patient-centric clinical trial model at the funding stage,Allens Long Journey(33 Years&Counting),Increase in Pulmonary Nodules,Increase in size of multiple pulmonary nodules,highly suspicious for metastases.,Ground-Glass Foci

3、 and Growth,Increase in size and number of patchy ground-glass foci.,Lymphadenopathy Observations,New mediastinal and left hilar lymphadenopathy.Appearance of metastases or multifocal lung adenocarcinoma are favoured.,CT Chest Report January 2017(Impression),Nodularity in Lower Lobe,More nodularity

4、in relation to a sub solid opacity in the lower lobe on the left.Imaging features represent progressive areas of multifocal adenocarcinoma with developing invasive adenocarcinoma.,Nodules and Nodes,Additional solitary nodules are noted.Highly suggestive of growing metastatic deposits.,CT Chest Repor

5、t March 2017(Impression),Next Generation Sequence Report,Androgen Receptor Signaling&Salivary Duct Carcinoma,Classification and Diversity,Salivary gland cancers comprise a small subset of human malignancies and are classified into multiple subtypes that exhibit diverse histology,molecular biology,an

6、d clinical presentation.,Local Disease Treatment,Local disease is potentially curable with surgery,which may be combined with adjuvant radiotherapy.However,metastatic or unresectable tumors rarely respond to chemotherapy and carry a poorer prognosis.,Metastatic Tumor Challenges,Recent molecular stud