一种双管齐下的大数据方法用于批判性分析南卡罗来纳州农村贫困居民中具有感染性的粪类圆线虫.pdf

1、A TWOA TWO-PRONGED BIG DATA APPROACH TO PRONGED BIG DATA APPROACH TO CRITICALLY ANALYZE CRITICALLY ANALYZE STRONGYLOIDESSTRONGYLOIDESSTERCORALISSTERCORALISINFECTIONS AMONG RURAL,INFECTIONS AMONG RURAL,IMPOVERISHED SOUTH CAROLINA IMPOVERISHED SOUTH CAROLINA RESIDENTSRESIDENTSDr.Matthew S.Haldeman,MD

2、MPHHenry Heidt,BSBACKGROUND AND SIGNIFICANCE Soil-transmitted helminths:a historical U.S.public health concern Strongyloides stercoralis:a small worm with big consequencesImage source:https:/www.cdc.gov/dpdx/strongyloidiasis/index.htmlBUT WHAT DOES THIS HAVE TO DO WITH SOUTH CAROLINA?Image source:Si

3、nger R,Sarkar S.Modeling strongyloidiasis risk in the United States.International Journal of Infectious Diseases.2020;100:366-372.doi:10.1016/j.ijid.2020.09.002Image source:https:/ PROBLEM:DESPITE ROBUST HISTORICALSURVEILLANCE,LITTLE IS KNOWN REGARDING THE CURRENT BURDEN OF STRONGYLOIDESIN THE SOUTH

4、EAST U.S.RESEARCH DESIGN AND METHODS Active surveillanceo Strongyloides IgG/IgM of banked serum samples from the ALL-IN studyo Demographic,socioeconomic,exposure data collated from ALL-IN questionnaires Passive surveillanceo Prisma Health electronic health records chart review for the 5-year period

5、8/16/2017-8/15/2022o Demographic,socioeconomic,risk factor,and health outcomes data recordedo 1:3 Case:Controls Statistics:Fishers Exact,Chi Square tests utilizing Stata 18PHASE 1 RESULTS:DATA ABSTRACTIONPHASE 1 DATA ABSTRACTION RESULTS Compared to controls,cases:oWere significantly more likely to a

6、 local exposure(significant time outdoors,gardening,hunting,etc.)Otherwise,we found no significant differences in:oRace/ethnicityoUrban vs.RuraloInternational traveloResided internationallyoSubstance useoEmployment statusoComorbidities:asthma,HIV,malnutritionoClinical outcomes of encounter:30d readm