1、2021AnnualReportLetter to ShareholdersJames.A.MishChief Executive Offi cerDear Fellow Shareholders,“Helps You Smoke Less.”These four words from the U.S.Food and Drug Administration(FDA)on December 23rd,2021,capped off an amazing year at 22nd Century Group and ushered in what may be the most disrupti
2、ve new tobacco product of our generation our VLN reduced nicotine content combustible cigarettes.VLN is designed specifically to help smokers smoke fewer cigarettes.In doing so,we can fulfill our primary mission to reduce the harm associated with smoking.Our VLN authorization reflects years of scien
3、tific research,federally funded clinical studies and regulatory persistence to secure the first and only Modified Risk Tobacco Product(MRTP)authorization granted to a combustible cigarette.It also signifies a new starting line as we bring VLN to the$800 billion global tobacco market 85%of which is f
4、ocused on combustible tobacco cigarettes.With more than 34 million smokers in the U.S.and more than a billion smokers around the world,this tremendous global market is ripe for disruption.In the U.S.,we know that more than three out of four adult smokers want to quit and 50%attempt to quit each year
5、.Yet less than 10%of smokers are able to successfully quit.More and more,smokers are actively seeking alternatives to addictive,conventional cigarettes,most of which are other addictive nicotine delivery systems.We offer adult smokers something different a way to reduce their smoking;a way to reduce
6、 their nicotine consumption.We are encour-aged by data from our own consumer perception studies showing that 60%of current adult smokers are likely to use VLN,and from extensive federally funded studies showing that reduced nicotine cigarettes like VLN are effective in helping smokers truly smoke le