1、NEURODEGENERATIVE DISORDERSDeciphering Nervous System DeclineCAS INSIGHTSTMNeurodegenerative diseases represent a spectrum of disorders that are characterized by the progressive destruction of cells and connections that make up the nervous system.These conditions are detrimental to the lives of mill

2、ions of people worldwide,ultimately leading to the collapse of the neural networks that are required for human function.1Alzheimers disease(AD),Parkinsons disease(PD),amyotrophic lateral sclerosis(ALS),multiple sclerosis,and polyglutamine(polyQ)diseases all belong to the neurodegenerative classifica

3、tion,and we will delve deeper into specific conditions throughout this report.25 In people with neurodegenerative disorders such as those aforementioned,cells of the nervous system,called neurons,are progressively damaged and destroyed,resulting in the breakdown of the core communicative connections

4、.1 Depending on the specific disease,this degeneration can lead to impaired memory,cognition,behavior,sensory,and/or motoric performance.1 Neurodegenerative diseases remain incurable,but certain disorders can be treated to provide symptomatic relief,improve quality of life,or limit disease progressi

5、on.Older age has been associated with an increased risk of developing a neurodegenerative condition,and the rise in longevity over the past decades has coincided with an increased incidence of neurodegenerative disorders.With an increasing aging population worldwide,effective treatment and managemen

6、t of these conditions becomes paramount.6It has been proposed that neurodegenerative diseases are defined by a set of common attributes,including pathological protein aggregation,synaptic and neuronal network dysfunction,aberrant proteostasis,cytoskeletal abnormalities,altered energy metabolism,DNA