NGDx_IVD市场变革中的分子酶开发-技术前沿与应用实践_Watchmaker_20250814_Shared.pdf

《NGDx_IVD市场变革中的分子酶开发-技术前沿与应用实践_Watchmaker_20250814_Shared.pdf》由会员分享，可在线阅读，更多相关《NGDx_IVD市场变革中的分子酶开发-技术前沿与应用实践_Watchmaker_20250814_Shared.pdf（46页珍藏版）》请在三个皮匠报告上搜索。

1、IVD市场变革中的分子酶开发技术前沿与应用实践张宇Watchmaker GenomicsAug 14,2025Watchmaker Genomics NGDx Conference Only Watchmaker Genomics NGDx Conference OnlyResearch Use Only|Do Not Distribute|18 August 2025|page 2BRIAN KUDLOW COFOUNDER&CSciOVice President of Research andDevelopment at ArcherDxSenior Scientist at Thermo

2、 FisherScientific Dharmacon(acquired byPerkinElmer Horizon)STEPHEN PICONE COFOUNDER&CStraOExecutive Director of Corporate Developmentat ArcherDXCo-Founder,CEO and Chief Strategy Officerat Enzymatics(acquired by Qiagen)Product management,Manufacture and QC atNew England BioLabsWatchmaker Genomics创始团队

3、分子酶领域的“梦之队梦之队”TREY FOSKETT CEO&COFOUNDERVice President of Sequencing and LifeScience Commercial Operations forRoche DiagnosticsCo-Founder and Chief Technology Officerof Kapa Biosystems(acquired by RocheDiagnostics)Watchmaker Genomics NGDx Conference Only Watchmaker Genomics NGDx Conference OnlyResea

4、rch Use Only|Do Not Distribute|18 August 2025|page 3报告内容1.分子酶市场及在IVD变革中面临的困境2.产品破局方向及分子酶开发前沿3.临床测序和分子诊断领域的实践案例-分子诊断：技术上台阶、产品下基层-临床测序：入院LDT、精准诊疗-创新检测：多模态标志物、免疫检测分子化Watchmaker Genomics NGDx Conference Only Watchmaker Genomics NGDx Conference OnlyResearch Use Only|Do Not Distribute|18 August 2025|page

5、4报告内容1.分子酶市场及在IVD变革中面临的困境2.产品破局方向及分子酶开发前沿3.临床测序和分子诊断领域的实践案例-分子诊断：技术上台阶、产品下基层-临床测序：入院LDT、精准诊疗-创新检测：多模态标志物、免疫检测分子化Watchmaker Genomics NGDx Conference Only Watchmaker Genomics NGDx Conference OnlyResearch Use Only|Do Not Distribute|18 August 2025|page 5什么是分子酶？具有化学催化活性的蛋白质或RNA，底物是核酸和碱基。将需要苛刻条件才能发生的化学反应变

6、得容易，转化效率变高，反应速率变快：高效性高效性：降低活化能，提高反应速率和产量。专一性专一性：识别特定底物，催化特定类型反应。温和性温和性：常温、常压等条件下进行。不稳定性不稳定性：酶结构和活性易受环境因素影响，导致酶活降低甚至失活。Watchmaker Genomics NGDx Conference Only Watchmaker Genomics NGDx Conference OnlyResearch Use Only|Do Not Distribute|18 August 2025|page 6分子酶的催化原理E+S ES EP E+P速率势能Watchmaker Genomics