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1、/As filed with the Securities and Exchange Commission on March 1,2023 Registration No.333-268025 UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington,D.C.20549 AMENDMENT NO.3TOFORM F-1/AREGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ZHONG YUAN BIO-TECHNOLOGY HOLDINGS LIMITED(Exact Name

2、 of Registrant as Specified in its Charter)Cayman Islands 2833 Not Applicable(State or Other Jurisdiction ofIncorporation or Organization)(Primary Standard IndustrialClassification Code Number)(I.R.S.EmployerIdentification No.)Suite 901,Tesbury Centre28 Queens Road EastWanchai,Hong KongTelephone:+85

3、2 2919-8916(Address,including zip code,and telephone number,including area code,of Registrants principal executive offices)Cogency Global Inc.122 East 42nd Street,18th FloorNew York,New York 10168Telephone:800-221-0102_(Name,address,including zip code,and telephone number,including area code,of agen

4、t for service)Copies to:Henry F.Schlueter,Esq.Celia Velletri,Esq.Schlueter&Associates,P.C.5290 DTC Parkway,Suite 150Greenwood Village,CO 80111Telephone:303-292-3883Mark E.Crone,Esq.Liang Shih,Esq.The Crone Law Group P.C.420 Lexington Avenue,Suite 2446New York,New York 10170Telephone:646-861-7891 App

5、roximate date of commencement of proposed sale to the public:As soon as practicable after the effective date of thisregistration statement.If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 underthe Securities Act of 1933,ch

6、eck the following box.If this Form is filed to register additional securities for an offering pursuant to Rule 462(b)under the Securities Act,check thefollowing box and list the Securities Act registration statement number of the earlier effective registration statement for the sameoffering./If this