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1、As filed with the Securities and Exchange Commission on February 25,2022UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWASHINGTON,D.C.20549_FORM 10-K(MARK ONE)Annual Report Pursuant to Section 13 or 15(d)of the Securities Exchange Act of 1934For the Fiscal Year Ended December 31,2021ORTransition Rep

2、ort Pursuant to Section 13 or 15(d)of the Securities Exchange Act of 1934For the transition period from to Commission File No.1-6571_Merck&Co.,Inc.2000 Galloping Hill RoadKenilworthNew Jersey07033(908)740-4000New Jersey22-1918501(State or other jurisdiction of incorporation)(I.R.S Employer Identific

3、ation No.)Securities Registered pursuant to Section 12(b)of the Act:Title of Each ClassTrading Symbol(s)Name of Each Exchange on which RegisteredCommon Stock($0.50 par value)MRKNew York Stock Exchange0.500%Notes due 2024MRK 24New York Stock Exchange1.875%Notes due 2026MRK/26New York Stock Exchange2.

4、500%Notes due 2034MRK/34New York Stock Exchange1.375%Notes due 2036MRK 36ANew York Stock ExchangeNumber of shares of Common Stock($0.50 par value)outstanding as of January 31,2022:2,527,733,606.Aggregate market value of Common Stock($0.50 par value)held by non-affiliates on June 30,2021 based on clo

5、sing price on June 30,2021:$196,870,000,000.Indicate by check mark if the registrant is a well-known seasoned issuer,as defined in Rule 405 of the Securities Act.Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d)of the Act.Yes No I

6、ndicate by check mark whether the registrant(1)has filed all reports required to be filed by Section 13 or 15(d)of the Securities Exchange Act of 1934 during the preceding 12 months(orfor such shorter period that the registrant was required to file such reports),and(2)has been subject to such filing