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1、AACR.org|PediatricCancerProgressReport.org|#PediatricCancerProgressReportSPOTLIGHT ON THE GLOBAL LANDSCAPE OF PEDIATRIC CANCERSISBN:979-8-9857852-9-6AACR.org|PediatricCancerProgressReport.org|#PediatricCancerProgressReportPLEASE CITE THIS REPORT AS:American Association for Cancer Research.AACR Pedia

2、tric Cancer Progress Report 2025.Accessed:Month Day,Year.Available from:LinkTABLE OF CONTENTSA Message From The AACR .1Executive Summary .3A Snapshot of Progress Against Pediatric Cancers in 2025 .12Pediatric Cancer Trends in the United States .14Saving Lives Through Research .14Ongoing Challenges i

3、n Pediatric Cancers .17Challenges of Rare Disease Research.20Uneven Progress Against Pediatric Cancers.22Pediatric Cancer Disparities.23Funding Pediatric Cancer Research:A Vital Investment .25Economic Toll of Pediatric Cancers.25Framework for Funding Pediatric Cancer Research.26Unraveling the Genomi

4、cs and Biology of Pediatric Cancers .29Molecular and Cellular Influences Driving Pediatric Cancers .30Genetic Alterations.31Germline Variants in Cancer Predisposition Genes .34Somatic Mutations .35Epigenetic Modifications.37Developmental Pathways Gone Awry.37Tumor Microenvironment.39Innovative Techn

5、ologies Decoding Pediatric Cancer Complexities .40Single-cell,Multi-omic,and Spatial Technologies.40CRISPR Gene Editing.41Research Model Systems.41Artificial Intelligence.43Liquid Biopsy.43Shared Data and Collaborations Advancing Pediatric Cancer Research .44Building and Connecting Data Networks .45

6、Integrating Molecular Insights Into Clinical Care.46Pediatric Cancer Predisposition and Surveillance .47Identifying Children With Cancer Predisposition Syndromes .47The Role of Distinctive Signs or Symptoms.48The Role of Genetic Testing.49The Role of Genetic Counseling.52Screening and Surveillance R