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1、TECH TREND REPORT August 2019The Future of Digital Health?1The pace and scale of digital health technology adoptions have accelerated over the past three years across the value chain.While high-profile setbacks such as Theranos tempered investor sentiment,two digital health startups,California-based

2、 diabetes management company Livongo and Utah-based health software firm Health Catalyst,recently made their market debuts in July this year,signaling an end to the three-year IPO drought in digital health.This report has been created in collaboration with the Plug and Play Health and Insurtech vert

3、icals.Our goal is to share some of the most prominent trends we have observed and a sample of the most notable startups that are helping to drive the healthcare transformation.The trends weve highlighted in this report-Digital Diagnostics,Remote Patient Monitoring,and On Demand Care-represent areas

4、where weve witnessed significant startup activities,and where our corporate partners have expressed strong interests in exploring.?2Through digital diagnostics,automated health assessments can be done electronically and virtually.This is especially useful in early disease prevention and prediction,w

5、ith the vision that it wont be too late any more for patients to treat themselves with incurable disease.For instance,nowadays we see a number of digital health startups pioneering research-back mobile solutions to help assess brain health and detect early symptoms of dementia,which is incurable onc

6、e diagnosed.The cost of healthcare and long-term case for individuals with Alzheimers disease or other dementias are substantial as$341,840 in 2018,according to the world Alzheimer report 2018.Many pharmaceuticals have attempted clinical trials on Alzheimers cure,but no one has seen any luck.Biogen

7、Inc and partner Eisai Co Ltd ended two late-stage trials of their experimental Alzheimers disease drug aducanumab earlier this year,losing more than$18 billion of its value on the announcement day.Trend Diagnostics Beyond the Hospital:At-Home Digital Disease Detection&PreventionThe convergence of ne

8、w technologies,value-based payment models,and consumer demand for personalized services are driving healthcare providers and payers to embrace innovation.From on-demand services,digital diagnostics,and patient monitoring,health system leaders are leveraging startups to deliver higher quality care at

9、 lower cost to patients,caregivers,and communities.Similarly,advanced analytics,customer insights,and new engagement strategies are enabling insurance carriers to acquire new customers,mitigate risks,and increase customer retention.?3Digital ways to detect and prevent critical and chronic diseases a

10、re going to break geographical barriers,making it possible to diagnose patients even outside of the clinic as early as possible.Today,different companies have developed their respective mobile applications and software programs to make remote diagnostics possible.In the future,it is anticipated that

11、 more companies would also create concierge programs to diagnose patients without having to be physically in front of each other.Through AI,well be able to do passive diagnostics on the basis of biometric data in the cloud.In different places all over the world,various approaches have been implement

12、ed in order to carry out diagnosis in a digital manner.Here are a few startups in our ecosystem pioneering digital diagnostics:Featured StartupMobileODT Ecosystem StartupDescription:MobileODT builds visual diagnostic systems that enable every primary care provider to conduct a specialist-level visua

13、l examination.MobileODTs Enhanced Visual Assessment(EVA)System is the first product,an FDA and CE approved mobile colposcope powered by an AI validated by the National Cancer Institute of the US to be able to accurately diagnose cervical cancer with greater reliability than Pap cytology(93%vs 71%).E

14、VA has an install base of+1200 Systems across the US,Europe,India,and Africa:used for over 40,000 procedures in 29 countries,for regular use and to support clinical trials for other diagnostics.Building on initial revenues from selling to clinics and hospitals,its pay-per-click services are launchin

15、g in 2019 to commercialize telemedicine and AI-based diagnostics.It is growing rapidly in new geographies and have in the pipeline additional visual-based applications,including ENT endoscopy,Oral disease,and Skin.?4A network of womens health care clinics in Alaska(Planned Parenthood of Greater Nort

16、hwest and Hawaii)recently purchased our EVA System for colposcopy,for use in their main clinic as a replacement for their existing medical device.Immediately they jumped on the telehealth and AI-diagnostic opportunities,and expanded their use from colposcopy to documentation and remote collaboration

17、 around pelvic pain,vulvar lesions,and STIs,training NPs and PAs to conduct examinations that used to wait for the Gynecologist to be available.They are now restructuring their budget to expand EVA to their 28 clinics across the State of Alaska,to provide point-of-care analysis(same day screening an

18、d colposcopy)to women in every location,and ensure immediate expert review of all at-risk cases by their gynecological staff at their central location.Competitive AdvantageUse CaseThe company has the largest installed base of Internet-connected,smart colposcopes in the world,and a broad array of pat

19、ents on imaging modalities for data collection.This enables them to maintain their data advantage(our database of cervical cases is unparalleled)and distribute over-the-air our software services to enable point-of-care diagnostics to replace Pap cytology in every place in which our EVA System is in

20、use.They priced their systems at a disruptive price point,and engineered for cost,enabling faster scale and distribution than any other company in the market.?5Featured Startup?5DescriptionTestC is a UK domiciled startup revolutionizing the direct to consumer healthcare diagnostics market.The compan

21、y has innovated a delivery mechanism that allows conditions to be diagnosed immediately in the comfort and convenience of home.TestCard enables an individual to take ownership of their health,making laboratory level information accessible and painless and thus enfranchising the individual and ultima

22、tely democratizing healthcare.TestCard Munich Batch 2,Portfolio(in progress)Competitive AdvantageTestCard is an at-home testing solution that provides immediate results at a low cost.TestCard is a combination of a non-invasive urine test kit embedded into a postcard,with an accompanying mobile appli

23、cation that turns a mobile phones camera into a clinical grade scanner.Use CaseTest card will be launching four products:1)Abusive Drugs-Top 10 Drugs Screen;2)Urinary Tract Infection;3)Pre-diabetes Check;4)Pregnancy&Ovulation Check The companys innovation is a diagnostic urinalysis(urine test)kit em

24、bedded into a postcard.The TestCard and the accompanying TestCard app,are not only a reliable and non-invasive alternative to costly and time-consuming doctor visits;but crucially,serve as an early diagnosis tool that prompts earlier medical intervention and treatment.TestCard is on course to disrup

25、t the global diagnostics market with the launch of its application in February 2017.?6Featured Startup?6Competitive Advantage:Altoida SV Health Batch 8,Munich Batch 2 Altoida built a first in class augmented reality based platform for digital biomarkers measuring real-world outcomes using smartphone

26、 sensors.Altoidas first product,Altoida NMI,is an FDA Class II Medical Device for early Alzheimers Disease detection up to 6+years pre-symptom with 94%accuracy.After close to two decades of research,Altoida has developed an iOS and Android based Augmented Reality Technology which tests the functiona

27、l&cognitive aptitude of a patient,via a self-learning(ML)algorithm.This revolutionary assessment test done on an iPad or Tablet,can be taken in the comfort of your home or at the doctors office.All data is automatically transmitted to the practitioner to aid with diagnosis.DescriptionHigh clinical a

28、ccuracy,sensitivity,specificity-FDA Cleared(2018),CE Approval(2019)-Reimbursable in the U.S.-Seasoned&multidisciplinary team?7?7Use Case:Using an augmented reality framework that allows testing of complex everyday functions in a gamified and fun way,while directly interacting with a users environmen

29、t and thus physically activating them,we are testing three major cognitive areas:Graphics by Altoida?8Featured Startup?8DescriptionBringing together experts from neurology,speech,machine learning and business,Aural Analytics is building the worlds most advanced multi-modal based brain health analyti

30、cs engine.Aural Analytics combines speech signal processing and cognitive linguistic analysis together into one powerful set of APIs that are easily extensible across the continuum of care for neurological diseases.Aural Analytics,Inc Ecosystem Startup Competitive AdvantageUse CaseDisease,location,l

31、anguage,device agnosticReal-time,online and easily extensibleDeployed in 8 languages and on 4 continentsClinically validated across multiple disease statesPharmaceutical customers use their technology to validate efficacy of drugs in clinical trials.Aural Analytics builds a custom mobile and cloud b

32、ased applications based on disease and deploy both in clinic and for patients at home.Clinicians,principally Speech Language Pathologists,use mobile app of Aural Analytics in their practice to receive real time analytics about their patients.Their patients also download the app and use it at home as

33、 needed.?9Trend Remote Patient Monitoring?9Before Remote Patient Monitoring(RPM),nurses were responsible for checking in on their patients,in person and often,leading to higher costs and inefficiency.However,with the help of new technologies,this process has improved.RPM allows physicians to keep an

34、 eye on their patients symptoms while empowering patients to take charge of their own health.This is part of a shift in culture,moving from merely focusing on caring for the sick to overall prevention of disease.Though this technology seems great,how easily is it adopted or integrated?In 2018,Curren

35、t Procedural Terminology(CPT)codes were released in order to incentivize providers to adopt RPM.These codes are used to report procedures and services to physicians and health insurance companies.According to Propeller,“the new CPT codes are better suited to reimburse for the realities of current te

36、chnology and staffing models.”Image:A few of the new CPT codes.Source:https:/ RPM works:RPM uses a wide range of technology such as video calls,data collection,and virtual monitoring to keep track of the progress of patients.This technology results in more frequent and seamless communication between

37、 health providers and patients,improving the health of patients and facilitating better treatment.?10?10 Benefits of RPM:Decrease costs:RPM has the potential to“save$200 billion in healthcare costs globally”according to a pilot done by CHRISTUS RPM pilot.Because of increased and improved communicati

38、on between their healthcare provider,patients also save money and have improved health in the long run.Saves time:By collecting data ahead of time,in person appointments can be more efficient,leading to lower costs.RPM also eliminates unnecessary visits,saving time for both the health provider and t

39、he patients.Early Detection+Reduced ReAdmittance Rates:Early prediction through the use of RPM is crucial because it decreases readmittance rates.In fact,the University of Pittsburgh Medical Center reduced the risk of readmission by 76%by using RPM technologies.But why is reducing readmittance rates

40、 so important?Firstly,according to studies published by the US National Library of Medicine,“the cost of readmissions to the healthcare system is substantial,accounting for an estimated$17.4 billion in spending annually by Medicare alone.”For this reason“new financial penalties for institutions with

41、 high readmission rates”were created in order to incentivize hospitals to decrease these rates.This is where RPMs ability for early detection can help.In the next few pages,we list some startups that are developing RPM technology to help bring about change in the healthcare industry.?11?11Descriptio

42、n:Harmonize Health sells health outcomes directly to customers,and handles all the technological overhead needed to do so.For customers,they manage their patients with minimal disruption to their daily workflows.For patients,their technology is best-in-class:often one tap,once per day,and thats it.F

43、eatured StartupHarmonize Health Ecosystem StartupCompetitive Advantage:They sell health outcomes directly to customers,and dont require them to build internal infrastructure to use us.Harmonize Health produce results with minimal burden required on customers.Since Harmonize Health is a complete end-

44、to-end product with great pilot results(50%reduction in utilization costs for high risk patients),they are able to adopt a cost-savings revenue model.This means that customers can pay little money up front,but they will then charge them a percentage of the cost savings they experience while using Ha

45、rmonize Health.?12?12Converted 1200 high risk patient pilot(age 65+,2+comorbidities)into a real customer.So far:$90 per patient per month,$50 per patient activation,up to 27,000 patients.Another cohort within these 27,000 patients will be subject to shared cost savings.This means the monthly fee is

46、reduced to$45,but we will obtain 15%of the cost savings every 6 months(customer has agreed to open medical claims data to us for audit).Use CaseHarmonize Healths patient facing platform is designed to operate out of the box with no setup required.?13?13Description:HealthBeats is a remote patient mon

47、itoring platform offering simple-to-use,simple to deploy and simple business model to health providers and patients.Healthbeast focuses on patients and providers by providing a one touch patience experience,a paperless process,as well as a subscription model.HealthBeats SV Health Batch 9Competitive

48、advantage:Health Beats built a simple product that would allow for regular monitoring outside of healthcare which would in turn lead to better health for patients.The teams extensive experience in healthcare allows them to work through the complexities in order to bring simple solutions to both part

49、icipants and providers alike.It is all about simplicity.Health Beats technology allows users to easily monitor their health.Featured Startup?14?14Description:Located in the heart of San Francisco,iBeat is a technology company empowering people to live longer lives.The team is currently working on a

50、breakthrough Wearable-as-a-Service that perpetually monitors and analyzes users 24-7 heart activity.In the case of a life-threatening emergency,iBeat will instantly alert the user,their loved ones,and emergency responders in real-time,helping ensure immediate care delivery and potentially saving the

51、 users life.iBeat WatchCompetitive Advantage:iBeat moves away from the previous generation of wearable watches/devices in providing more useful health data,which encourages users to constantly use the device.Competitors include:Life AlertPhillips Life Alert,PAI healthThis smartwatch monitors your he

52、art rate and can potentially save your life.Featured Startup?15?15Description:BloomLife is a developer of prenatal care solutions designed to improve the health of moms and babies.The companys solutions combine pregnancy specific wearables with data analytics,to reassure mom and to provide doctors w

53、ith better data to earlier predict and manage pregnancy complications.Their wearable monitor is a lightweight patch that non-invasively tracks important health parameters of mom and baby throughout pregnancy(fetal movement,fetal heart rate,contractions,maternal health).The device connects to a smart

54、phone app and backend cloud analytics,enabling population health management for providers.BloomLife Portfolio StartupBloomlifes technology is a wearable device that can monitor a mothers contractions and collect other data in order to detect complications.Featured Startup?16?16Description:VivaLNK of

55、fers connected healthcare solutions including an IoT medical wearable sensor and data platform that continuously monitors patient vitals and biometrics from any location.Patient monitoring applications built on our platform include chemo treatment,heart failure,and hypertension.VivaLNK SV Health Bat

56、ch 8Use Case:VivaLNKs wearable deviceHad class 2 FDA approval for its remote thermometer deviceECG sensor battery lasts for up to 3 daysInsurance use case includes group benefit and corporate wellness cost reduction by adopting their solutionRaised series B last year with post valuation 70M USDFeatu

57、red Startup?17?17Trend Health On DemandIn todays day and age of one-click everything-shopping,delivery,transportation-the average consumer has become accustomed to convenience,personalization,and instant service.For anyone who has tried to see a doctor in the last few years,these are not the words y

58、ou would likely use to describe the experience.A handful of startups are trying to change that.We bucket these startups into what we would call“on-demand healthcare”,or in other words,startups that are making healthcare services more accessible,easier to understand,and deliverable in a way that work

59、s for each persons day-to-day life.In this section,we explore a handful of these“on-demand”startups to see how theyre bridging the gap between todays consumers and traditional healthcare.?18Featured StartupsDescription:Heal leverages technology and logistics to re-humanize the practice of medicine i

60、n a way that is fulfilling for both doctors and patients alike.Heal sends a licensed,background-checked pediatrician or family doctor to its customers,on-demand,on their schedule,for$159,or for an in-network co-pay with select insurance plans.The startup is live in Los Angeles,Orange County,San Fran

61、cisco,Silicon Valley,and San Diego from 8AM to 8PM,seven days a week with an eye to expand to additional markets.Competitive Advantage:More startups than we can count have used the tagline“Were the Uber for Healthcare”.Its a catchy way to conceptualize a business,but more often than not,the logistic

62、s and unit economics of healthcare dont lend themselves to an uber-like model.That being said,Heal is one of the rare startups making it work.With thoughtful geographic expansion and smart partnerships with health plans,Heal is growing a loyal user base that enjoys the convenience and personalized n

63、ature of house calls.Heal Portfolio StartupUsers begin by requesting and scheduling a doctors appointment via the Heal app.From there,they can determine whether to use insurance to cover the cost,or pay a flat fee.Heal appointments are appropriate for pediatric care,primary care,some urgent care,and

64、 general prevention and wellness.Return users will be able to access their history with Heal via the app,and can request to see the same doctor to facilitate continuity of care.Use Case:?19Description:Gyant helps hospitals,health plans,and pharma companies engage and support patients at scale.Gyants

65、 accessible,chat-based AI takes a medical history and navigates patients to the appropriate next step,including a visit to the doctor,labs,or an efficient telemedicine encounter on Gyants platform.Proactive check-ins keep patients engaged and supported along the patient journey.Competitive Advantage

66、:The chatbot landscape is crowded,but Gyant stands out for its superior user experience,and the flexibility of the platform.Gyants founders come from the gaming world,which is reflected in the quality of the platform.Where other healthcare experiences are typically sterile,dull,or even painful,Gyant

67、 brings color,humanity,and joy.Their chatbot is conversational and fun,while still gathering information and moving the user through the encounter.What users dont see is the heavy lifting done by Gyant on the backend.The platform translates the consumers chat into medically relevant information that

68、 is formatted appropriately for both clinicians and any systems that require integration,like EMRs.Gyant Portfolio,Cleveland Batch 1Gyant is live in a number of different applications,including triage and follow up following a patients discharge from hospital.Patients used to receive receive check-i

69、n phone calls from nurses after they were discharged from the hospital,but people have stopped answering their phones these days.With Gyant,the hospital can send a text,which patients have been shown to be more likely to answer.Gyant asks patients how they are doing,and can escalate appropriately if

70、 a patient needs additional care.This approach is saving health systems time and money,and improving outcomes,too.Use Case:Featured Startup?20Description:Meru health is online digital clinic that offers an app-based treatment program that is supported by licensed therapists.The easy-to-access digita

71、l program helps improve the lives of people living with depression and saves on healthcare costs.Meru Healths digital clinic offers an app-based treatment program that is supported by licensed therapists.Meru Health individualizes the program based on patients personal information and needs.Competit

72、ive Advantage:Meru differs from other app-based mental health programs in that it is a full-blown digital clinic.Right from the first call until the final week,a licensed Meru Health therapist actively supports participants to become empowered and recover.The program also sets itself apart from othe

73、r similar offerings because it is both reimbursable via insurance plans,and showing tremendous clinically significant results in published studies.Meru Health Portfolio,SV Health Batch 9Currently,a number of large employers are partnered to offer Meru Health as an employee benefit.Employees sign up

74、for the program and are then guided through a 12 week course structured around weekly themes which build upon each other.It includes elements of mindfulness-based,cognitive behavioral,and behavioral activation therapy.Use Case:Featured Startup?21Each of the companies highlighted represents a unique

75、approach to tackling a specific problem,and while theyre all having success in their own areas of the market,wed be happy to discuss further examples to meet your needs.Plug and Play is launching a smart health program to bring pharmaceuticals,hospitals and health insurance providers together to tra

76、nsform the healthcare industry.Please contact for more information.22References“Biogen Halts Study of Alzheimers Drug,a Blow to Hopes for New Treatment.”STAT,22 Mar.2019, Halts Study of Alzheimers Drug,a Blow to Hopes for New Treatment.”STAT,22 Mar.2019, of RPM:Reducing Healthcare Costs.”Skedulo,11

77、Apr.2019, al.“Reducing Hospital Readmission Rates:Current Strategies and Future Directions.”Annual Review of Medicine,U.S.National Library of Medicine,2014,www.ncbi.nlm.nih.gov/pmc/articles/PMC4104507/.Matthews,Melanie.“Infographics:Drivers of Remote Patient Monitoring.”Healthcare Intelligence Netwo

78、rk,2017, UPM,Remote Patient Monitoring Helps Reduce ER Utilization and Hospital Readmissions.”Healthcare IT News,2018, educe-er-utilization-and-hospital-readmissions.Steenhuysen,Julie.“Biogen Scraps Two Alzheimer Drug Trials,Wipes$18 Billion from.”Reuters,Thomson Reuters,21 Mar.2019, Guide to the New CPT Codes for Remote Patient Monitoring(RPM).”Propeller Health,2 Aug.2019,