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KRAS突变中G12突变在各类癌症中的类型及占
KRAS突变中G12突变在各类癌症中的类型及占
行业数据
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图片大小：372KB
图片尺寸：1108*759
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所属报告：
艾力斯-伏美替尼商业化进入放量期-221217（27页）.pdf
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相关数据
图表12G7国家OECD综合领先指标指示截至8月
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行业数据
2026-05-09
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Exhibit 13： OCED data shows on average ~12% of elderly are receiving long-term care in institutions; among the individual countries there’s scope for low social welfare countries (e.g. US) to increase penetration significantly
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行业数据
2026-03-11
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图表9去年12月，G7国家OECD综合领先指标同比回升，或指向5月中国出口增
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行业数据
2026-01-20
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全球范围内目前已上市的5款KRAS抑制剂
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行业数据
2026-01-07
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KRAS（OFF）抑制剂机理
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行业数据
2026-01-07
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KRAS（ON）抑制剂机理
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行业数据
2026-01-07
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KRAS（ON/OFF）抑制剂机理
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行业数据
2026-01-07
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图12：2025年G+独立安全事件分类统计
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行业数据
2025-12-29
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图表11KRAS在肺癌（NSCLC）、结直肠癌（CRC）、胰腺癌（PDAC）突变情况
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行业数据
2025-11-21
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图表12KRAS靶点开发历程
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产业概述
2025-11-21
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欧美G12国家IP授权玩具份额逐年提升
fCDlubTku70gICAgICAgfCBHMTIgSVDmjojmnYPnjqnlhbfku73pop0gfAp8LS0tLS0tLS0tLS0tfC0tLS0tLS0tLS0tLS0tLS0tLS0tfAp8IDIwMjIgICAgICAgfCAzMCUgICAgICAgICAgICAgICAgfAp8IDIwMjMgICAgICAgfCAzMS4xMCUgICAgICAgICAgICAgfAp8IDIwMjQgICAgICAgfCAzNCUgICAgICAgICAgICAgICAgfAp8IDIwMjRIMSAgICAgfCAzMiUgICAgICAgICAgICAgICAgfAp8IDIwMjVIMSAgICAgfCAzNSUgICAgICAgICAgICAgICAgfAoK6LWE5paZ5p2l5rqQ77yaQ2lyY2FuYeOAgeW8gOa6kOivgeWIuOeglOeptuaJgA==
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行业数据
2025-11-10
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和誉ABSK043的临床定位以及未来结合EGFR/KRAS等小分子抑制剂在NSCLC中布局的管线矩阵
fCDkurrnvqQgICB8IEVHRlJtdXQgfCBLUkFTbXV0IHwKfC0tLS0tLS0tfC0tLS0tLS0tLXwtLS0tLS0tLS18Cnwg6KW/5pa55Lq6576kIHwgMjAlICAgICB8IDI1JSAgICAgfAp8IOS6mua0suS6uue+pCB8IDUwJSAgICAgfCAxMCUgICAgIHwKCui1hOaWmeadpea6kO+8muWFrOWPuFBQVA==
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行业数据
2025-10-10
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表18、靶向KRASG12C以外KRAS靶点全球竞争格局（临床阶段）
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竞争格局
2025-07-24
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G12切片成本差异（元/片）
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行业数据
2025-05-20
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M10N和G12RN电池片非硅成本拆分（行业平均水平）
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行业数据
2025-05-14
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行业数据
2026-07-30
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KRAS 突变是 RAS 基因家族突变中最常见的一种，约占 85%。KRAS 处于许多重要细胞信号通路网络的中枢位置，与肿瘤的发生和发展密切相关。正常情况下KRAS 基因收到外界刺激信号，在核苷酸转换因子（GEF）的帮助下与三磷酸鸟苷（GTP）结合从而被激活。而 G12C 突变会阻止 KRAS 与 GTPase 激活蛋白（GAP）结合，从而阻止 GTP 水解，使得 KRAS 持续处于活化状态，引发下游级联反应，进而引起肿瘤的发生。
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