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NSCLC常见基因突变类型
NSCLC常见基因突变类型
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所属报告：
君实生物-创新赋能国际化新征程多产品助力抗疫-220316（48页）.pdf
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行业数据
2026-07-14
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KRASG12C一线治疗NSCLC竞争格局（截至2026-6-25）
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2026-07-01
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行业数据
2026-07-01
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行业数据
2026-05-28
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行业数据
2026-05-28
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行业数据
2026-03-13
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各药物针对IO耐药NSCLC临床数据汇总
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行业数据
2026-03-13
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驱动基因阴性晚期NSCLC治疗格局
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竞争格局
2026-02-24
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NSCLC1L全球竞争格局AK112BNT327707
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竞争格局
2026-01-28
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SI-B001针对PD-(L1)抑制剂治疗失败的野生型NSCLC的mPFS数据
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行业数据
2025-12-26
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图表4国NSCLC驱动基因谱
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行业数据
2025-12-03
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图表20EGFR耐药后NSCLC试验数据比
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行业数据
2025-12-03
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图表11KRAS在肺癌（NSCLC）、结直肠癌（CRC）、胰腺癌（PDAC）突变情况
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行业数据
2025-11-21
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NSCLC1L全球竞争格局AK112BNT327707
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肺癌可进一步分为非小细胞肺癌和小细胞肺癌（SCLC）。其中，NSCLC 的靶向疗法研究较多。NSCLC 按照病理学状态可分为 I~IV 期，鳞状和非鳞状；按照基因突变类型可分为无基因驱动、EGFR 驱动、ALK 驱动、MET 驱动、KRAS驱动等分型。目前，NSCLC 成为肿瘤免疫治疗的热门领域，大部分免疫制剂布局了 NSCLC 一线、二线疗法，涵盖基因驱动型和非基因驱动型，在PD-L1阳性和表达＜1%的 NSCLC 种均展示出一定疗效。
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