lymphomas, thyroid cancer, and germ cell tumors. Although survival exceeds 90 percent for some cancers, such as Hodgkin pediatric cancers than non-Hispanic Whites. Children and lymphoma, thyroid carcinoma, and retinoblastoma, others, including high-grade gliomas and certain sarcomas, remain areas also face higher mortality, often due to limited access to specialized centers, clinical trials, and supportive services. among the deadliest, with survival rates below 20 percent. The economic toll of pediatric cancers is substantial. The average cost of cancer care per child, including hospitalization aggressive and rarer subtypes of pediatric cancers. and lost wages for parents, can approach $833,000 over the course of treatment and survivorship. Projections show that and international collaborations and partnerships. National and 2050 will exceed $594 billion globally, however, strategic investments can yield up to $2.6 trillion in lifetime productivity initiatives, such as Project:EveryChild of the Children's gains—-a four-fold return on investment. Initiative (MCI) of the National Cancer Institute (NCI), research between 2015 and 2024. Unfortunately, private- data for common and rarer pediatric cancers. International sector investments, which are pivotal to developing drugs and conducting clinical trials required for regulatory approvals, have lagged for pediatric cancers, making sustained federal and philanthropic support critical to continued progress. clinical trials. These collective efforts aim to ensure that all therapies and precision medicine approaches. clinical trials, bridging critical gaps left by the industry. Despite the public and philanthropic investments, the annual support for pediatric cancer research falls short. Sustaining pediatric cancers persist across racial, ethnic, geographic, and socioeconomic groups. For example, Hispanic children have strengthening partnerships among federal agencies, industry, the highest cancer incidence rates in the United States, while with cancer has the chance to survive and thrive. non-Hispanic Black children experience the lowest survival,
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