Foundations Overview of Necessary Equipment Set-Up and Practical Application for Invasive Ex-ercise Testing.pptx

1、November 14,2025,Foundations:Overview of Necessary Equipment,Set-Up,and Practical Application for Invasive Exercise Testing,Greg Lewis MDMass General Brigham Heart and Vascular Institute Director of Heart FailureJeffrey and Mary Ellen Jay Endowed Chair in Heart FailureDirector,CPET LaboratoryProfess

2、or of Medicine,Harvard Medical Schoolglewismgb.org,Disclosures,Research Grant Support or Advisory Board/Steering Committee Roles-NHLBI(U01 Heartshare Network,R01 HL119154,R01HL 151841R01 HL159514)-AHA Strategically Focused Research Network-American Regent,Alexion,Amgen,Applied Therapeutics,Astra Zen

3、eca,Cardiage,Cytokinetics,Edwards,Lilly,Novo Nordisk,NXT,Pfizer,Pharmacosmos,Rivus,NYHA,KCCQ,accelerometry,+Degree of volitional effort+Reproducibility and lack of training effect+Identification of exercise-limiting organ system,Cardiopulmonary Exercise Testing,Invasive Cardiopulmonary Exercise Test

4、ing,+Direct hemodynamic measures+Pressure-flow relationships+Gold standard definition of central vs.peripheral limitation,Comparison of Methods to Quantify Functional Limitations in Heart Failure:Rationale for Ex Hemodynamics,Equipment for Invasive Hemodynamic Exercise Testing,Belkin M et al AHA Sci

5、entific Statement 2025,in press,Belkin M et alAHA Scientific Statement 2025In press,Cycle Ergometer-Zero watt unloaded exercise-Programmable continuous incremental ramping-Metabolic cart interface,Metabolic Cart-Interfaced with wireless ECG&Cycle-transfer delay time of 1 second,-calibration stabilit

6、y of 3%over 20 minutes,Co-oximeterBlood gas measurements,Hemodynamic monitoring station-Record serial pressure tracings-Perform thermodilution cardiac outputs,PA Line Mixed Venous Samples,Radial ArterialLine Samples,Permits Direct Fick Cardiac Outputs,Staffing of Invasive Hemodynamic Exercise Tests,