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渤健Biogen(BIIB)2025年10-K年度报告「NASDAQ」(英文版)(212页).pdf

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1、UNITED STATES SECURITIES AND EXCHANGE COMMISSIONWashington,D.C.20549Form 10-KANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d)OF THE SECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31,2025orTRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)OF THE SECURITIES EXCHANGE ACT OF 1934Commissio

2、n file number:0-19311BIOGEN INC.(Exact name of registrant as specified in its charter)Delaware33-0112644(State or other jurisdiction of incorporation or organization)(I.R.S.Employer Identification No.)225 Binney Street,Cambridge,MA 02142(617)679-2000(Address,including zip code,and telephone number,i

3、ncluding area code,of Registrants principal executive offices)Securities registered pursuant to Section 12(b)of the Act:Title of Each ClassTrading Symbol(s)Name of Each Exchange on Which RegisteredCommon Stock,$0.0005 par valueBIIBThe Nasdaq Global Select MarketSecurities registered pursuant to Sect

4、ion 12(g)of the Act:NoneIndicate by check mark if the registrant is a well-known seasoned issuer,as defined in Rule 405 of the Securities Act.Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d)of the Act.Yes No Indicate by check mar

5、k whether the registrant(1)has filed all reports required to be filed by Section 13 or 15(d)of the Securities Exchange Act of 1934during the preceding 12 months(or for such shorter period that the registrant was required to file such reports),and(2)has been subject to such filingrequirements for the

6、 past 90 days.Yes No Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 ofRegulation S-T(232.405 of this chapter)during the preceding 12 months(or for such shorter period that the registrant was require

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1. **公司概况**:Biogen是全球生物制药公司,专注于神经学、专科免疫学和罕见病领域,核心产品包括多发性硬化症(MS)药物、脊髓性肌萎缩症(SPINRAZA)、弗里德赖希共济失调(SKYCLARYS)等。 2. **关键业务发展**: - 2025年完成收购Alcyone Therapeutics($8500万),开发CNS给药平台。 - 与Eisai合作推广阿尔茨海默病药物LEQEMBI,获中国、日本等多国批准;与Supernus合作推广产后抑郁症药物ZURZUVAE。 - 新增合作:Dayra(口服大环肽)、Vanqua(C5aR1拮抗剂)、City Therapeutics(RNAi疗法)等。 3. **财务数据**:2025年总营收依赖TYSABRI(>10%)和SPINRAZA(>10%);通过发行17.5亿美元债券优化债务结构。 4. **研发进展**: - LEQEMBI皮下注射剂获FDA受理;SPINRAZA高剂量 regimen在欧盟获批。 - 罕见病管线:zorevunersen(Dravet综合征)进入III期,salanersen(SMA)预计2026年启动III期。 5. **战略调整**:出售TOFIDENCE和BYOOVIZ权益,聚焦核心领域;终止BIIB143(DPN)项目。
**Biogen新药进展?** **阿尔茨海默病疗法?** **罕见病治疗突破?**
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