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Crinetics Pharmaceuticals-2026-JPM.pdf

上传人: 明**** 编号:1069838 2026-01-17 18页 2.65MB

1、JANUARY 2026Beyond Innovation to Impact:Building the Premier Endocrinology BusinessJ.P.Morgan Healthcare ConferenceAngela Living with AcromegalyForward Looking Statements and Legal DisclaimersForward Looking Statements:This presentation contains forward-looking statements.Crinetics Pharmaceuticals,I

2、nc.(“Crinetics,”the“company,”“we,”“us,”or“our”)cautions you that all statements other than statements of historical facts contained in this presentation are forward-looking statements.Such forward-looking statements include,but are not limited to,statements regarding:our ability to effectively comme

3、rcialize PALSONIFY(paltusotine)to become a market leader or a“blockbuster”;our estimates relating to market size,or our ability to drive diagnosis and treatment for undiagnosed patients;the plans and timelines approval of paltusotine outside the US;the plans and timelines for a Phase 3 program,regul

4、atory filings or approval of paltusotine for carcinoid syndrome,for atumelnant for CAH and for atumelnant for ACTH-dependent Cushings syndrome;the ability of atumelnant to transform CAH treatment or to become a“blockbuster”therapy for CAH;the ability of CRN09682 to become a“blockbuster”for neuroendo

5、crine tumors or other SST2+tumors;the plans and timelines for the clinical development of our drug candidates,including the therapeutic potential and clinical benefits or safety profile thereof;and the expected timing for the initiation of clinical trials or the potential benefits of our development

6、 candidates in patients across multiple indications;the expected timing of additional research pipeline updates or the expected timing of the advancement of those programs;and the expected timing through which our cash,cash equivalents,and short-term investments will fund our operating plans or its

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1. **核心产品进展**:PALSONIFY(paltusotine)已上市用于肢端肥大症,2025年第四季度初步未审计净产品收入约1.4亿美元;atumelnant治疗先天性肾上腺皮质增生症(CAH)的II期数据积极,已启动III期试验;CRN09682(非肽药物偶联物)针对SST2+肿瘤的I/II期试验启动。 2. **市场潜力**:PALSONIFY在肢端肥大症(美国患者约3.6万)和类癌综合征(美国1.8万-3.4万)中具有“重磅炸弹”潜力;atumelnant在成人CAH(美国约1.2万)和儿科CAH(约5000)中有望革新治疗;CRN09682针对神经内分泌肿瘤(美国1.1万-2.1万)及其他SST2+肿瘤。 3. **财务与研发**:现金及等价物约14亿美元,可支持运营至2030年;拥有7+临床管线候选药物,涵盖内分泌领域多个适应症,目标成为领先内分泌企业。
**市场前景如何?** **新药进展怎样?** **患者受益几何?**
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