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Prime Medicine Corporate Presentation _JPM Corporate Presentation.pdf

上传人: 明**** 编号:1069795 2026-01-17 41页 3.39MB

1、1Delivering on the promise of Prime EditingCorporate PresentationJanuary 20262This presentation contains forward-looking statements of Prime Medicine,Inc.(Prime,we or our)within the meaning of the Private Securities Litigation Reform Act of 1995,as amended.These forward-looking statements contain in

2、formation about our current and future prospects and our operations,which are based on currently available information.All statements other thanstatements of historical facts contained in this presentation,including statements regarding our strategy,projects and plans are forward-looking statements.

3、In some cases,you can identifyforward-looking statements by terminology such as“aim,”“anticipate,”“assume,”“believe,”“contemplate,”“continue”“could,”“design,”“due,”“estimate,”“expect,”“goal,”“hope,”“intend,”“may,”“might,”“objective,”“opportunity,”“plan,”“predict,”“positioned,”“possible,”“potential,”

4、“project,”“seek,”“should,”“strategy,”“target,”“will,”“would”and other similar expressionsthat are predictions of or indicate future events and future trends,or the negative of these terms or other comparable terminology.These forward-looking statements include,but are not limitedto,express or implie

5、d statements about Primes beliefs and expectations regarding:the potential of Prime Editing to correct the causative mutations of diseases,including CGD,Wilson Disease,CF,and AATD;the continued development and advancement of its AATD and Wilson Disease programs,including the timing of the filing of

6、IND and/or CTA applications in mid-2026 and 1H 2026,respectively,and the timing of initial data for both programs in 2027;the initiation,timing,progress and results of our research and development programs,preclinical studies and future clinicaltrials,including the release of data related thereto;th

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1. **Prime Editing技术优势**:最 versatile 基因编辑技术,可永久校正基因突变,不引起双链断裂或旁观者编辑,潜在可解决90%以上遗传疾病。 2. **核心管线进展**: - Wilson病(PM577):2026年H1提交IND/CTA,2027年公布初步数据,针对H1069Q突变(欧美患者超2万)。 - AATD(PM647):2026年年中提交IND/CTA,2027年公布数据,目标患者20万(欧美)。 - CGD(PM359):临床数据显示快速植入、恢复酶活性,无严重不良反应。 3. **合作与资金**:与BMS达成超35亿美元里程碑合作,开发CAR-T疗法;获囊性纤维化基金会资助推进CF项目。 4. **平台化策略**:模块化LNP递送系统加速肝管线开发,PASSIGE技术支持大片段基因插入。 5. **知识产权**:持有18项核心专利,覆盖Prime编辑技术全流程。
**Prime Editing前景?** **基因编辑新突破?** **治愈遗传病可能?**
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