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Mereo-jp-morgan-presentation-january-2026.pdf

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1、Mereo BioPharmaJ.P.Morgan ConferenceDisclaimerThis presentation has been prepared by Mereo BioPharma Group plc(the“Company”)solely for your information and for the purpose of providing background information on the Company,its business and the industry in which it operates or any particular aspect t

2、hereof.For the purposes of this notice,“presentation”means this document,any oral presentation,any question and answer session and any written or oral material discussed or distributed during any related presentation meeting.This presentation has not been independently verified and no representation

3、 or warranty,express or implied,is made or given by or on behalf of the Company or any of its subsidiaries,or any of any such persons directors,officers,employees,agents,affiliates or advisers,as to,and no reliance should be placed on,the accuracy,completeness or fairness of the information or opini

4、ons contained in this presentation and no responsibility or liability is assumed by any such persons for any such information or opinions or for any errors or omissions.All information presented or contained in this presentation is subject to verification,correction,completion and change without not

5、ice.In giving this presentation,none of the Company or any of its subsidiaries,or any of any such persons directors,officers,employees,agents,affiliates or advisers,undertakes any obligation to amend,correct or update this presentation or to provide the recipient with access to any additional inform

6、ation that may arise in connection with it.To the extent available,the data contained in this presentation has come from official or third-party sources.Third party industry publications,studies and surveys generally state that the data contained therein have been obtained from sources believed to b

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1. **公司概况**:Mereo BioPharma聚焦罕见病,拥有两个关键项目(Setrusumab、Alvelestat)及临床阶段项目Vantictumab,现金储备约4100万美元,支撑运营至2027年中。 2. **Setrusumab(成骨不全症)**:两项III期试验未达主要终点(年化骨折率降低),但显示显著骨密度提升(*P*<0.0001)及椎体骨折减少(59%,*P*=0.081),改善疼痛与功能。 3. **Alvelestat(AATD-LD)**:计划启动III期,采用双主要终点(SGRQ总评分、CT肺密度),目标纳入约220名患者, partnering进行中。 4. **Vantictumab(骨硬化症)**:已授权āshibio(保留欧权),2026年H2提交IND,临床前数据显示可改善骨结构。
骨折疗法有效吗? 肺病新药进展如何? 骨质疏松有希望吗?
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