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Biohaven-2026-JPM.pdf

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1、 2026 Biohaven,Ltd.All rights reserved.44th Annual J.P.Morgan Healthcare ConferenceJanuary 12,2026Vlad Coric,M.D.Chairman and Chief Executive OfficerCAMERONLiving with Graves DiseaseForward-Looking StatementThis presentation includes forward-looking statements within the meaning of the Private Secur

2、ities Litigation Reform Act of 1995,including statements about Biohaven Ltd.(the“Company”)and our planned and ongoing trials(including those for our taldefgrobep alfa,opakalim,BHV-2100,BHV-8000,BHV-1300,BHV-1400,BHV-1510 and BHV-1600 development programs),the timing of and the availability of data f

3、rom our clinical trials,the timing and our decisions to proceed with our planned regulatory filings,the timing of and our ability to obtain regulatory approvals for our product candidates,the clinical potential utility of our product candidates,alone and as compared to other existing potential treat

4、ment options,and the potential advancement of our early phase programs including BHV-1310,BHV-1530 and BHV-1500.The use of certain words,including“continue”,“plan”,“will”,“believe”,“may”,“expect”,“anticipate”and similar expressions,is intended to identify forward-looking statements.Investors are cau

5、tioned that any forward-looking statements,including statements regarding the future development,timing and potential marketing approval and commercialization of our development candidates are not guarantees of future performance or results and involve substantial risks and uncertainties.Actual resu

6、lts,developments and events may differ materially from those in the forward-looking statements as a result of various factors including:the expected timing,commencement and outcomes of Biohavens planned and ongoing clinical trials;the timing of planned interactions and filings with the Food and Drug

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1. **核心产品进展**:BHV-1400(IgA肾病)和BHV-1300(Graves病)计划2026年启动关键试验;BHV-1400单次给药48小时降低Gd-IgA1 63.3%,BHV-13004周降低IgG超80%。 2. **癫痫治疗**:Opakalim(Kv7激活剂)开放标签研究中50%患者6个月内癫痫频率降低50%,且中枢神经系统副作用低于竞品。 3. **肥胖治疗**:Taldefgrobep(肌肉生长素抑制剂)启动II期,目标为每月一次给药,安全性优于同类药物(肌肉痉挛率3% vs. 30%-73%)。 4. **肿瘤领域**:BHV-1510(Trop2 ADC)联合PD-1抑制剂在难治性患者中客观缓解率达73%;BHV-1530(FGFR3 ADC)首例患者给药无剂量限制毒性。 5. **财务与市场**:2025年Q3现金2.64亿美元,自上次季度融资3.12亿美元;IgAN美国潜在市场规模超200亿美元。
**IgAN新疗法?** **Graves病突破?** **癫痫新希望?**
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