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Erasca Corporate Presentation_2026-01.pdf

上传人: 明**** 编号:1069723 2026-01-17 31页 3.31MB

1、On a Journey to Erase CancerErasca Corporate PresentationJanuary 2026Eric and his wife Margaret,inspiring our bold mission to erase cancer2We caution you that this presentation contains forward-looking statements.All statements other than statements of historical facts contained in this presentation

2、,including statements regarding our future results of operations and financial position,business strategy,research and development plans,the anticipated timing(including the timing of initiation and the timing of data readouts),costs,design and conduct of our ongoing and planned preclinical studies

3、and clinical trials for our product candidates,the potential therapeutic benefits and potential patient population for each of our product candidates,our intellectual property protection,the timing and likelihood of success of our plans and objectives,the impact of the deprioritization of certain pr

4、ograms,and future results of anticipated product development efforts,are forward-looking statements.In some cases,you can identify forward-looking statements by terms such as“may,”“will,”“should,”“expect,”“plan,”“anticipate,”“could,”“intend,”“target,”“project,”“contemplates,”“believes,”“estimates,”“

5、predicts,”“potential”or“continue”or the negative of these terms or other similar expressions.The inclusion of forward-looking statements should not be regarded as a representation by us that any of our plans will be achieved.Actual results may differ from those set forth in this presentation due to

6、the risks and uncertainties inherent in our business,including,without limitation:our expectations regarding the potential therapeutic benefits of our product candidates,including ERAS-0015 and ERAS-4001,and our planned advancement of our development pipeline,including the anticipated timing of data

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1. **公司使命与愿景**:Erasca致力于“消除癌症”,目标每年为至少10万患者提供治疗,聚焦RAS/MAPK通路抑制。 2. **核心管线**: - **ERAS-0015**(Pan-RAS分子胶):潜在最佳同类药物,临床前活性比竞品高5-10倍,预计专利保护至2043年。 - **ERAS-4001**(Pan-KRAS抑制剂):潜在首创/最佳同类药物,选择性抑制KRAS,保留H/NRAS野生型,专利保护至2043年。 3. **临床进展**: - **AURORAS-1试验**(ERAS-0015):2026年H1将公布I期数据,已观察到低剂量(8mg QD)的部分缓解。 - **BOREALIS-1试验**(ERAS-4001):2026年H2启动I期。 4. **财务与团队**:现金储备3.62亿美元,支撑运营至2028年下半年;团队及科学顾问委员会在RAS领域经验丰富。
**癌症新疗法?** **RAS通路突破?** **ERAS-0015潜力?**
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