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EGFR突变类型占比
EGFR突变类型占比
行业数据
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所属报告：
艾力斯-伏美替尼商业化进入放量期-221217（27页）.pdf
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第二代EGFR-TKI不同企业竞争格局
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竞争格局
2026-01-08
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第一代EGFR-TKI不同企业竞争格局
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竞争格局
2026-01-08
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Iza-bren已开展临床研究的癌种（左图中以红字标明）以及EGFR和HER3在各种上皮肿瘤中的
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行业数据
2025-12-26
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EGFR/HER3ADC全球格局
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竞争格局
2025-12-26
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图表20EGFR耐药后NSCLC试验数据比
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行业数据
2025-12-03
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和誉ABSK043的临床定位以及未来结合EGFR/KRAS等小分子抑制剂在NSCLC中布局的管线矩阵
fCDkurrnvqQgICB8IEVHRlJtdXQgfCBLUkFTbXV0IHwKfC0tLS0tLS0tfC0tLS0tLS0tLXwtLS0tLS0tLS18Cnwg6KW/5pa55Lq6576kIHwgMjAlICAgICB8IDI1JSAgICAgfAp8IOS6mua0suS6uue+pCB8IDUwJSAgICAgfCAxMCUgICAgIHwKCui1hOaWmeadpea6kO+8muWFrOWPuFBQVA==
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行业数据
2025-10-10
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EGFR突变NSCLC患者推荐用药（CSCO及NCCN指南）
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行业数据
2025-09-23
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截至2025年9月，全球共6款EGFR单抗ADC药物进入临床
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2025-09-23
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几乎所有患者在使用第一代 EGFR-TKI 药物 1-2 年会出现耐药性，其中 50%以上出现 TKI 耐药是由于发生了 T790M 突变，伏美替尼二线用药市场空间充足。EGFR T790M 突变导致 ATP 在与 EGFR-TKI 竞争中胜出，优先与 EGFR 结合，导致第一代和第二代 EGFR-TKI 药物的失效。第三代 EGFR-TKI 能有效与 EGFR和 T790M 突变位点结合，抑制由 T790M 突变造成的耐药。
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