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图表64常用细胞培养狂犬病疫苗比较
图表64常用细胞培养狂犬病疫苗比较
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图片大小：241KB
图片尺寸：2355*894
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所属报告：
智飞生物-代理起家锤炼营销能力自研产品打造第二生长曲线-220211（53页）.pdf
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行业数据
2026-07-27
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图10：b|按国家和经验划分，在内容发现方面重度Al使用者的占比
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行业数据
2026-07-21
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图6：丨按国家划分的使用各AI工具的受访者比例(渗透率，%)
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行业数据
2026-07-21
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图6：.政府和民间投资及经常账户赤字占国内生产总值的
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狂犬病疫苗的发展大致可以分为两代。第一代狂犬病疫苗为神经组织疫苗。尽管经过许多年不断改进，利用山羊或绵羊脑组织（Semple）或乳鼠脑组织（Fuenzalida）生产的灭活 NTVs 都伴有神经系统的不良反应。且由于 NTVs 的效价低于 CCVs，需要接种次数可多达 23 次/天。由于 NTVs 价低且易获得，少数国家（主要在东南亚）目前仍在使用 NTVs。第二代狂犬病疫苗为细胞培养疫苗（CCVs）。CCVs 系将病毒经细胞或鸡胚培养增殖后灭活制成，例如人二倍体细胞、恒河猴胎儿细胞、叙利亚仓鼠肾细胞、Vero 细胞、鸡胚细胞或鸭胚细胞等，其中Vero 细胞是目前应用最为广泛的细胞基质。根据采用的细胞规模化培养方式，可分为罐培养工艺（片状载体，微载体），转瓶培养工艺。这些疫苗都可用于暴露前或暴露后免疫预防，全球已经有数百万人接种了 CCVs。CCVs所用毒株为固定的 I型基因型毒株。实验室动物研究和人体临床评估已经证明了 CCVs 的免疫原性和效力，在用于暴露前和暴露后预防时，对 99%以上的受接种者均可诱导出抗体反应。在10年以前接受过CCVs暴露前全程免疫接种、免疫接种一年后给予一剂次加强接种的人群中，有 96%以上的人仍然可以检测到 NVA。
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