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Destiny-Breast01试验不良事件
Destiny-Breast01试验不良事件
行业数据
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所属报告：
医疗行业深度报告：创新驱动ADC药物发展加速-220609（58页）.pdf
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ACE-Breast-01响应率结果
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行业数据
2022-06-13
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Destiny-Breast01试验患者肿瘤体积缩小比例
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行业数据
2022-06-13
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Destiny-Breast03响应率结果
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行业数据
2022-06-13
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DESTINY-CRC01主要疗效数据
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行业数据
2022-01-19
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DESTINY-Lung01HER2过表达队列自基线病灶变化最佳百分比
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行业数据
2022-01-19
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DESTINY-Breast03研究PFS数据（BICR评估）
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行业数据
2021-10-18
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图46、《Destiny2》国区活跃人数占比
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行业数据
2021-07-02
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2026-07-30
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2026-07-30
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2026-07-30
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2026-07-30
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安全性方面，在 184 例患者中 TEAE 率为 99.5%，消化系统及血液毒性是发生率最高的不良事件。3 级以上不良事件率为 50.2%，13.6%的患者出现了间质性肺病。主要为 3 级以下程度，减量停药并及时给予糖皮质激素可有效控制 ILD 的严重程度。
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