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图表63DVD-Ig平台设计的是四价双抗
图表63DVD-Ig平台设计的是四价双抗
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2021年生物医药行业双抗药物研发分析报告（42页）.pdf
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日本VTR、DVD、CD播放器在20世纪80-90年代保有量迅速提升（台（每100户））
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fCDmipdFR0ZSIHwg5oqXSEVSMyB8IHd0IEZjIGxnRzEgfAp8LS0tLS0tLS0tfC0tLS0tLS0tLXwtLS0tLS0tLS0tLS0tfAp8IOe6ouiJsuaWueWdlyB8IOiTneiJsuaWueWdlyB8IOeBsOiJsuaWueWdlyAgICB8
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2007年日本蓝光DVD份额首次超过高清
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2000年后日本DVD销量反超VTR但随后又迅速没落
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fCDmlbDmja7nsbvlnosgfCDmj4/ov7AgfAp8IC0tLSB8IC0tLSB8Cnwg5beu5byC5YyW5L2c55So5py655CGIChNb0EpIHwg5Lqy5ZKM5Yqb5pu05aW9IHwKfCDogZrnsbsgfCDmnInmlYjpqbHliqjlhY3nlqvnu4bog57mv4DmtLsgfAp8IOadoeS7tuaApyB8IOW8uuWkp+eahOWxgOmDqOaKl+iCv+eYpOS9nOeUqCB8Cnwg54us54m555qE5Y+M5oqX57uT5p6EIHwg5Y+q5pyJMTUtMjDkuKrmsKjln7rphbjkv67ppbDnmoTlpKnnhLbkurrmupDmipfkvZPlvaLlvI8gfAp8IOaYk+S6jueUn+S6p+S4lOebruWJjeS4uuiAkOWPl+aAp+iJr+WlvSB8ICB8CgrotYTmlpnmnaXmupDvvJpGLXN0YXIg5a6Y572R77yM6ZW/5rGf6K+B5Yi456CU56m25omA
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Netflix流媒体用户数接棒DVD用户数持续增长（单位：万人）
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fOW5tOS7vXzku5jotLnnlKjmiLfop4TmqKHvvIjkuIfkurrvvIl85aKe6YCf77yIJe+8iXwKfC0tLXwtLS18LS0tfAp8MjAwMXw0Nnw4OCV8CnwyMDAyfDg2fDc0JXwKfDIwMDN8MTQ5fDc2JXwKfDIwMDR8MjYxfDYwJXwKfDIwMDV8NDE4fDUxJXwKfDIwMDZ8NjMyfDUxJXwKCui1hOaWmeadpea6kO+8muWliOmjnuWFrOWRiu+8jOWbveiBlOivgeWIuOeglOeptuaJgA==
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公司是一家研究型生物制药企业，公司在全球各地共有超过 3万名员工。公司凭借拥较强的研发实力开发了修美乐（阿达木单抗），该款单抗自 2002年上市，连续 8年位居全球最畅销药物榜单首位。公司建立了 DVD-Ig（Dual Variable Domain-Ig）双抗技术平台，通过在正常 IgG抗体的轻链和重链的 N末端或 C末端连接另外的 VH或 VL结构域以形成双特异性抗体，因此 DVD-Ig双抗每个轻链和重链包含两个可变域，从而形成四价双抗，具有更高的特异性结合能力。DVD-Ig双抗保留了来自其两种亲本抗体的抗原结合特异性、亲和力和生物学活性，具有较高稳定性。利用该平台，公司目前已经成功研发了 ABT-122、ABT-981和 ABT-165三款双抗药物，目前均已完成 II期临床。
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2021年生物医药行业双抗药物研发分析报告（42页）.pdf
图表9国外企业双抗管线的布局较为丰富
图表8已进入III期临床阶段的双抗药物情况
图表7全球双抗研发管线目前大多仍处于临床早期阶段
图表64Abbvie通过自研和引进的方式持续丰富双抗管线
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