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麦肯锡(McKinsey):2025重构药物研发:生物制药行业创新挑战的应对策略研究报告(中译版)(107页).pdf

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1、RewiR&DMaking more medicines that matterJanuary 2025RewiR&D:Making more medicines that matter is published by McKinseys Life Sciences Practice.McKinsey&Company1200 19th Street NWFl.10-11,Suite 1100Washington,DC 20036Editors:Jermey Matthews,Mark Staples,Gwyn HerbeinArt director:LEFFCommunications:Sha

2、nnon Ensor,Emily M.KiernanProject management:Wendy ZhangLead reach and engagement partner:Gregory GravesThis publication is not intended to be used as the basis for trading in the shares of any company or for undertaking any other complex or significant financial transaction without consulting appro

3、priate professional advisers.No part of this publication may be copied or redistributed in any form without the prior written consent of McKinsey&Company.Copyright 2025 McKinsey&Company.All rights reserved.ContentsMaking more medicines that matterProductivity in biopharmaceutical R&D has slumped for

4、 a decade or more.We propose a recipe for sustainable,value-creating innovation,even in the face of strengthening industry headwinds.Charting the path to patientsCareful development of asset strategy across the pharmaceutical R&D pipeline is increasingly important in embracing opportunities for inno

5、vation.How biopharmaceutical leaders optimize their portfolio strategiesLeading biopharmaceutical companies manage their clinical pipelines to optimize for risk and reward.Heres how.Strengthening the R&D operating model for pharmaceutical companiesRevisiting the operating model could help pharmaceut

6、ical companies improve R&D productivity.Accelerating clinical trials to improve biopharma R&D productivityBiopharma sponsors are seeking to accelerate clinical trials and reduce costs through a set of targeted actions aimed at improving patient and site engagement and enrollment productivity.Operati

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本文主要讨论了生物制药研发(R&D)的资产策略,以应对日益增长的竞争压力和资产生命周期的缩短。文章提出了三种策略来优化资产结果: 1. 扩大适应症范围和并行化:领先的公司正在迅速扩大适应症范围,并积极启动更多试验,以在竞争对手进入市场前最大化收入。 2. 增加试验终点数量:增加试验的终点数量可以收集更多数据,支持监管审批、扩大标签选项、促进更广泛的市场准入,并最终鼓励患者和医疗提供者更广泛地采用。 3. 扩大全球试验足迹:扩大试验足迹可以增强临床计划的稳健性和普适性。 文章还指出,资产策略的优化需要战略和运营的进步。在战略方面,AI支持的预测分析正在改变公司识别和优先考虑新适应症的方式。在运营方面,试验设计和执行的改进正在创造协同效应,进一步增强并行化。 总体而言,资产策略的优化对于应对日益增长的竞争压力和资产生命周期的缩短至关重要。
生物制药研发生产力下降的原因是什么? 如何通过资产策略优化提高生物制药研发生产力? 生物制药公司如何利用人工智能提高研发效率?
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