1、Table of ContentsAs filed with the United States Securities and Exchange Commission on January 13,2025Registration No.333-UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington,D.C.20549FORM S-1REGISTRATION STATEMENTUNDERTHE SECURITIES ACT OF 1933Adagio Medical Holdings,Inc.(Exact name of registr
2、ant as specified in its charter)Delaware 001-42199 99-1151466(State or other jurisdiction of incorporation or organization)(Commission File Number)(I.R.S.Employer Identification Number)26051 Merit Circle,Suite 102Laguna Hills,California 92653(949)348-1188(Address,Including Zip Code,and Telephone Num
3、ber,Including Area Code,of Registrants Principal Executive Offices)Todd UsenChief Executive Officer26051 Merit Circle,Suite 102Laguna Hills,California 92653(949)348-1188(Name,Address,Including Zip Code,and Telephone Number,Including Area Code,of Agent for Service)Copies to:Michael S.LeeMichael Sande
4、rsReed Smith LLP599 Lexington AvenueNew York,New York 10022(212)521-5400If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933,check the following box.If this Form is filed to register additional
5、 securities for an offering pursuant to Rule 462(b)under the Securities Act,please check the following box and list the Securities Act registration statement number of theearlier effective registration statement for the same offering.If this Form is a post-effective amendment filed pursuant to Rule
6、462(c)under the Securities Act,check the following box and list the Securities Act registration statement number of the earlier effective registrationstatement for the same offering.If this Form is a post-effective amendment filed pursuant to Rule 462(d)under the Securities Act,check the following b