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世界卫生组织:2025 HIV临床管理建议报告:基于公共卫生途径的建议(英文版)(108页).pdf

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1、WHO Antiretroviral therapy and management guidelinesWHO updated recommendations on HIV clinical management:recommendations for a public health approachWHO updated recommendations on HIV clinical management:recommendations for a public health approachWHO updated recommendations on HIV clinical manage

2、ment:recommendations for a public health approachISBN 978-92-4-011946-8(electronic version)ISBN 978-92-4-011947-5(print version)World Health Organization 2025Some rights reserved.This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence(CC BY-NC-SA 3.0 IG

3、O;https:/creativecommons.org/licenses/by-nc-sa/3.0/igo).Under the terms of this licence,you may copy,redistribute and adapt the work for non-commercial purposes,provided the work is appropriately cited,as indicated below.In any use of this work,there should be no suggestion that WHO endorses any spe

4、cific organization,products or services.The use of the WHO logo is not permitted.If you adapt the work,then you must license your work under the same or equivalent Creative Commons licence.If you create a translation of this work,you should add the following disclaimer along with the suggested citat

5、ion:“This translation was not created by the World Health Organization(WHO).WHO is not responsible for the content or accuracy of this translation.The original English edition shall be the binding and authentic edition”.Any mediation relating to disputes arising under the licence shall be conducted

6、in accordance with the mediation rules of the World Intellectual Property Organization(http:/www.wipo.int/amc/en/mediation/rules/).Suggested citation.WHO updated recommendations on HIV clinical management:recommendations for a public health approach.Geneva:World Health Organization;2025.Licence:CC B

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1. **WHO更新HIV临床管理指南**:发布2025年新建议,聚焦公共卫生方法,优化抗逆转录病毒治疗(ART)、垂直传播管理和结核病(TB)预防。 2. **ART优化**: - 达芦那韦/利托那韦(DRV/r)为首选蛋白酶抑制剂(PI),阿扎那韦/利托那韦(ATV/r)或洛匹那韦/利托那韦(LPV/r)为替代选项。 - 替诺福韦(TDF/TAF)和阿巴卡韦(ABC)可重复用于后续治疗,基于疗效和成本优势。 - 首次推荐长效注射剂卡博特韦/利匹韦林(CAB/RPV)作为特定人群的替代方案。 3. **垂直传播管理**: - 婴儿出生后接受6周单药预防(奈韦拉平优先),高风险婴儿用三药方案。 - 支持HIV阳性母亲母乳喂养至12个月或更长,配合ART和婴儿预防措施。 4. **TB预防**: - 优先推荐3个月每周异烟肼+利福喷丁(3HP),替代方案包括6/9个月每日异烟肼(6H/9H)。 5. **目标与影响**:降低HIV/TB死亡率与传播,推动2030年消除艾滋病公共卫生威胁。
艾滋病新疗法? 母婴如何阻断? 结核病预防?
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