6. Christian Cajochen - HCL - 超越我们的眼睛光的非视觉影响.pdf

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1、 Christian Cajochen,PhD Centre for Chronobiology Psychiatric Hospital of the University of Basel,Switzerland Human Centric Lighting-beyond our eyes:the non-visual impact of light European Lighting Summit,Brussels,30.03.2017 Thomas Edison was probably wrong Buttgereit,Smolen,Coogan,Cajochen,Nat Rev R

2、heumatol,2015 Light is the most important Zeitgeber!Induction of a Phase Delay in the Human Circadian Melatonin Rhythm by Light(10000 lux for 6.5 h)Khalsa et al.,J Physiol(London)2003 Time of Day 12 24 12 24 12 24 12 24 12 Plasma Melatonin(pMol/L)0 100 200 300 400 Light Midpoint 4:45 Midpoint 8:21 L

3、ight and human circadian rhythms Melatonin as the best circadian marker in humans Sleep period Retina-4-3-2-1 0 1 2 3 4 0 3 6 9 12 15 18-3-6-9-12-15-18 Initial Phase(time relative to DLMO=0)Phase shift(h)Khalsa,et al.,J Physiol(London)2003 6.7 hours 10000 lux polychromatic white light Phase-Response

4、 Curve Light and circadian phase Light impacts on our circadian rhythms more powerfully than any drug Charles Czeisler Casting light on sleep deficiency Nature,2013 Suppression of melatonin in a totally blind person with bright light Sighted Person Time of Day(h)36.0 36.5 37.0 37.5 200 300 100 Plasm

5、a Melatonin(pmol/liter)Core Body Temperature(C)Blind Person 12 18 24 6 12 18 24 6 12 36.0 36.5 37.0 37.5 200 300 100 Core Body Temperature(C)Plasma Melatonin(pmol/liter)12 18 24 6 12 18 24 6 12 Czeisler et al.,New Engl Med 1995 Time of Day(h)Light is more than vision non-visual/non-image forming lig

6、ht effects Light can be seen without conscious vision*Forced choice test in a totally blind person 100 80 60 40 20 0 420 460 481 500 506 515 540 560 580 Wavelength(nm)Correct Answer(%)Nach Zaidi et al.,Curr Biol,2007 SCN(circadian Pacemaker)Retina Cones Eye A dual sensory organ Rods Non-classical Ph