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1、 =AchievedPOTENTIAL APPROVALS US/EUPLANNED SUBMISSIONS US/EUPOTENTIAL CLINICAL DATASum of Check ChangeSum of Check ChangeSum of Check ChangePhase IIIOPSUMIT(macitentan)USOPSUMIT(macitentan)USSIMPONI(golimumab)P P TREMFYA(guselkumab)EUPediatric Pulmonary Arterial Hypertension(TOMORROW)Pediatric Pulmo
2、nary Arterial Hypertension(TOMORROW)EUPediatric Ulcerative ColitisCrohns Disease(GALAXI)P PUSOPSYNVI(macitentan/tadalafil STCT)UPTRAVI(selexipag)STELARA(ustekinumab)P P TREMFYA(guselkumab)EUPulmonary Arterial HypertensionP PEUPediatric Pulmonary Arterial Hypertension(SALTO)P PEUPediatric Crohns Dise
3、aseUlcerative Colitis Monotherapy(QUASAR)P PUSEDURANT(rilpivirine)REKAMBYSUSTREMFYA(guselkumab)P P RYBREVANT(amivantamab)EUHIV pediatric 2-12 year oldP PEUHIV AdolescentsPediatric PsoriasisSubcutaneous(PALOMA-3)P PUSBALVERSA(erdafitinib)USnipocalimabP PUSTREMFYA(guselkumab)ERLEADA(apalutamide)EUUrot
4、helial Cancer(THOR)EUGeneralized Myasthenia GravisP PEUCrohns Disease(GALAXI)High Risk Prostate Cancer(PROTEUS)USDARZALEX(daratumumab)USSPRAVATO(esketamine)monotherapyUSTREMFYA(guselkumab)P P seltorexantFrontline multiple myeloma transplant eligible(PERSEUS)Treatment Resistant Depression(TRD4005)Ped
5、iatric Juvenile Psoriatic ArthritisAdjunctive treatment for major depressive disorder with insomnia symptomsP PUSCARVYKTI(ciltacabtagene autoleucel)P PUSRYBREVANT(amivantamab)P PUSTREMFYA(guselkumab)P P nipocalimabP PEURelapsed Refractory multiple myeloma w/1-3 PL(CARTITUDE-4)P PEUSubcutaneous(PALOM
6、A-3)P PEUUlcerative Colitis Monotherapy(QUASAR)Generalized Myasthenia GravisP PUSRYBREVANT(amivantamab)P PUSDARZALEX(daratumumab)USTREMFYA(guselkumab)TREMFYA(guselkumab)P PEUFrontline Non Small Cell Lung Cancer in combination with chemotherapy(PAPILLON)P PEUFrontline multiple myeloma transplant elig
7、ible(PERSEUS)Ulcerative Colitis Subcutaneous Induction(ASTRO)Crohns Disease Subcutaneous Induction(GRAVITI)USRYBREVANT/lazertinibP PUSTREMFYA(guselkumab)aticaprantEUNon Small Cell Lung Cancer 2L(MARIPOSA-2)P PEUCrohns Disease Subcutaneous Induction(GRAVITI)Adjunctive Major Depressive Disorder(VENTUR
8、A 1)USRYBREVANT/lazertinibP P SPRAVATO(esketamine)monotherapyEUNon Small Cell Lung Cancer(MARIPOSA)Treatment Resistant Depression(TRD4005)DARZALEX(daratumumab)Amyloidosis(ANDROMEDA)Phase IIJNJ-4804 Co-antibody TherapeuticPsoriatic Arthritis(AFFINITY)P P nipocalimabSjogrens Disease(DAHLIAS)TAR-200(RI
9、S/gemcitabine plus cetrelimab)Non Muscle Invasive Bladder Cancer(SunRISe-1)Johnson&Johnson Innovative Medicine PipelineKey Events in 2024*This information is as of July 17,2024 to the best of the Companys knowledge.Johnson&Johnson assumes no obligation to update this information.BALVERSA US Full Approval